Document Detail

Respiratory stress response: a novel diagnostic method for detection of significant coronary artery disease from finger pulse wave analysis during brief respiratory exercise.
MedLine Citation:
PMID:  20234302     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Respiratory maneuvers can uncover manifestations of myocardial ischemia. Some pulse wave characteristics are associated with significant coronary artery disease (S-CAD). An innovative test using the respiratory stress response (RSR) has been developed for the detection of S-CAD based on spectral analysis of finger pulse wave oscillations measured using photoplethysmography (PPG) during deep, paced breathing at a rate of 6 breaths per minute (0.1 Hz) for 70 seconds. We evaluated this test (RSR) as an indicator of S-CAD.
METHODS: The study consisted of 2 stages--feasibility and validation--assessing RSR in patients referred for coronary angiography. RSR was calculated by proprietary software analysis of the relative spectral power of the respiratory peak area at 0.1 Hz. The coronary angiograms were analyzed visually (stage I) and by quantitative coronary angiography (stage II) by 1 cardiologist blinded to the RSR results. S-CAD was defined as luminal stenosis >70% of at least 1 coronary artery or LM stenosis >50%.
RESULTS: A total of 193 consecutive patients (stage I: 98 and stage II: 95) with a mean age of 63.2 +/- 11.9 years, 70% men, 112 (58%) with S-CAD, were included. S-CAD patients had significantly lower RSR compared with patients without S-CAD, P < 0.001. RSR yielded a sensitivity of 83% (95% confidence interval = 75-90) and specificity of 70% (95% confidence interval = 59-80) for indicating S-CAD. Multivariate logistic regression analysis, adjusted for risk factors, showed that RSR is a strong independent indicator of S-CAD [OR = 18.9 (7.2-49.5), P < 0.001].
CONCLUSION: Reduced RSR is an accurate noninvasive indicator of S-CAD.
Arthur Shiyovich; Jamal Jafari; Yosi Blaer; Harvey Rehby; Ian Orlov; Dganit Cohen; Amos Katz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  339     ISSN:  1538-2990     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-13     Completed Date:  2010-06-02     Revised Date:  2011-02-22    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  440-7     Citation Subset:  AIM; IM    
Cardiology Department, Barzilai Medical Center, Ashkelon, Israel.
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MeSH Terms
Cohort Studies
Coronary Angiography
Coronary Artery Disease / diagnosis*
Exercise Test / methods*
Heart Rate
Middle Aged
Odds Ratio
Pulsatile Flow
Regional Blood Flow
Reproducibility of Results
Respiratory Mechanics / physiology*
Sensitivity and Specificity
Severity of Illness Index
Retraction In:
Am J Med Sci. 2011 Feb;341(2):169   [PMID:  21273842 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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