Document Detail


Respiratory modulation of premotor cardiac vagal neurons in the brainstem.
MedLine Citation:
PMID:  20452467     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The respiratory and cardiovascular systems are highly intertwined, both anatomically and physiologically. Respiratory and cardiovascular neurons are often co-localized in the same brainstem regions, and this is particularly evident in the ventral medulla which contains presympathetic neurons in the rostral ventrolateral medulla, premotor parasympathetic cardioinhibitory neurons in the nucleus ambiguus, and the ventral respiratory group, which includes the pre-Botzinger complex. Anatomical studies of respiratory and cardiovascular neurons have demonstrated that many of these neurons have projections and axon collateral processes which extend into their neighboring cardiorespiratory regions providing an anatomical substrate for cardiorespiratory interactions. As other reports in this Special Issue of Respiratory Physiology & Neurobiology focus on interactions between the respiratory network and baroreceptors, neurons in the nucleus tractus solitarius, presympathetic neurons and sympathetic activity, this report will focus on the respiratory modulation of parasympathetic activity and the neurons that generate parasympathetic activity to the heart, cardiac vagal neurons.
Authors:
Olga Dergacheva; Kathleen J Griffioen; Robert A Neff; David Mendelowitz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-05-07
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  174     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2011-03-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  102-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Pharmacology and Physiology, The George Washington University, Washington, DC 20037, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / cytology*
Heart / physiology*
Humans
Medulla Oblongata / physiology
Motor Neurons / physiology*
Respiration*
Vagus Nerve / physiology*
Grant Support
ID/Acronym/Agency:
HL49965/HL/NHLBI NIH HHS; HL59895/HL/NHLBI NIH HHS; HL72006/HL/NHLBI NIH HHS; R01 HL049965/HL/NHLBI NIH HHS; R01 HL049965-19/HL/NHLBI NIH HHS; R01 HL049965-21/HL/NHLBI NIH HHS; R01 HL059895/HL/NHLBI NIH HHS; R01 HL059895-13/HL/NHLBI NIH HHS; R01 HL059895-14/HL/NHLBI NIH HHS; R01 HL072006/HL/NHLBI NIH HHS; R01 HL072006-08/HL/NHLBI NIH HHS; R01 HL072006-09/HL/NHLBI NIH HHS
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