Document Detail

Respiratory function in patients with stable anorexia nervosa.
MedLine Citation:
PMID:  19581349     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The impact of undernutrition on lung physiology and respiratory muscle performance is still incompletely investigated. The purpose of this study was to assess the functional consequences of malnutrition on the respiratory system in stable patients with anorexia nervosa (AN). METHODS: Pulmonary function tests, maximal inspiratory pressure (Pimax), maximal expiratory pressure (Pemax), and the parameters of control of breathing were obtained in 27 patients with AN (mean [+/- SD] age, 24 +/- 7 years; BMI, 16 +/- 1 kg/m(2); duration of disease, 6 +/- 6 years) and in a group of matched healthy subjects. RESULTS: Compared with control subjects, significant reductions in the diffusing capacity of the lung for carbon monoxide (Dlco) and lung diffusion capacity corrected for alveolar ventilation (p < 0.001), which progressively worsened with the duration of disease, were found in the AN group. Only the membrane diffusing capacity was reduced in patients with AN (p < 0.05), while pulmonary capillary blood volume was similar to that of control subjects. Lung density measurements based on CT scan analysis were normal in a subgroup of eight patients with AN with low Dlco. Both Pimax and Pemax were decreased in patients with AN (p < 0.001), but the mild-to-moderate impairment to generate force of the respiratory muscles did not progress with time. In these patients with AN, the parameters of control of breathing were in the normal range and were comparable to those of control subjects. CONCLUSIONS: The functional alterations found in patients with AN indicate the presence of the progressive enlargement of peripheral lung units without relevant alveolar septa destruction. In the first 3 years of disease, appreciable weakness of respiratory muscles develops in patients with stable AN without further impairment over time.
Giovanni Gardini Gardenghi; Enrico Boni; Patrizia Todisco; Fausto Manara; Andrea Borghesi; Claudio Tantucci
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Publication Detail:
Type:  Journal Article     Date:  2009-07-06
Journal Detail:
Title:  Chest     Volume:  136     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-06     Completed Date:  2010-01-06     Revised Date:  2010-05-05    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1356-63     Citation Subset:  AIM; IM    
Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy.
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MeSH Terms
Anorexia Nervosa / physiopathology*
Blood Gas Analysis
Blood Volume
Body Mass Index
Capillaries / physiopathology
Carbon Monoxide / analysis
Forced Expiratory Volume
Lung / physiopathology
Pulmonary Alveoli / physiopathology
Reference Values
Respiratory Function Tests*
Vital Capacity
Young Adult
Reg. No./Substance:
630-08-0/Carbon Monoxide
Comment In:
Chest. 2010 May;137(5):1252-3; author reply 1253   [PMID:  20442133 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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