Document Detail

Respiratory function in healthy late preterm infants delivered at 33-36 weeks of gestation.
MedLine Citation:
PMID:  23140884     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare pulmonary function testing including respiratory compliance (Crs) and time to peak tidal expiratory flow to expiratory time (TPTEF:TE) at term corrected age in healthy infants born at 33-36 weeks of gestation versus healthy infants delivered at term.
STUDY DESIGN: We performed a prospective cohort study of late preterm infants born at 33-36 weeks without clinical respiratory disease (<12 hours of >0.21 fraction of inspired oxygen) and studied at term corrected age. The comparison group was term infants matched for race and sex to the preterm infants and studied within 72 hours of delivery. Crs was measured with the single breath occlusion technique. A minimum of 50 flow-volume loops were collected to estimate TPTEF:TE.
RESULTS: Late preterm infants (n = 31; mean gestational age 34.1 weeks, birth weight 2150 g) and 31 term infants were studied at term corrected age. The late preterm infants had decreased Crs (1.14 vs 1.32 mL/cm H(2)O/kg; P < .02) and decreased TPTEF:TE (0.308 vs 0.423; P < .01) when compared with the term infants. Late preterm infants also had an increased respiratory resistance (0.064 vs 0.043 cm H(2)O/mL/s; P < .01).
CONCLUSIONS: Healthy late preterm infants (33-36 weeks of gestation) studied at term corrected age have altered pulmonary function when compared with healthy term infants.
Cindy McEvoy; Sridevi Venigalla; Diane Schilling; Nakia Clay; Patricia Spitale; Thuan Nguyen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-06
Journal Detail:
Title:  The Journal of pediatrics     Volume:  162     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-04-26     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  464-9     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Mosby, Inc. All rights reserved.
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MeSH Terms
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Lung / physiology*
Lung Compliance / physiology*
Prospective Studies
Respiratory Function Tests
Grant Support
Comment In:
J Pediatr. 2013 Mar;162(3):443-4   [PMID:  23260100 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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