| Respiratory effects of changing the volume load imposed on the peripheral venous system. | |
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MedLine Citation:
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PMID: 20398805 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to determine if acute distension of the hindlimb venous circulation stimulates breathing, thereby contributing to the respiratory responses to rapid changes in total blood volume. In 10 spontaneously breathing anesthetized sheep, we withdrew 15 ml kg(-1) of blood from a femoral vein over approximately 1-2 min. We then compared the respiratory effects of infusing this venous blood back into the femoral veins across two conditions: the inferior vena cava (IVC) was either unobstructed or obstructed by a balloon-tipped catheter. We found that when blood was withdrawn and blood volume decreased, an absolute increase in breathing often occurred, but more importantly that a relative hyperventilation was always observed. When this blood was re-infused into the animal, effectively increasing blood volume, the respiratory response depended upon whether or not the IVC was open or obstructed. With the IVC unobstructed, a relative hypoventilation occurred, accompanied by an increase in alveolar PCO(2). In contrast, when the venous blood was re-infused and the IVC was obstructed, ventilation increased significantly, and the response was often hypocapnic. These results indicate that increasing the volume load in the venous circulation increases breathing, and that the transduction mechanism is contained within the peripheral venous system. Further, the respiratory drive from this sensory mechanism is subject to modulation via changes in the circulatory status, most likely within the arterial side. |
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Authors:
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Philippe Haouzi; Harold J Bell |
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Publication Detail:
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Type: Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 171 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-21 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 175-80 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Pennsylvania State University, College of Medicine, Division of Pulmonary Medicine, Heart and Vascular Institute, Penn State Hershey Medical Center, Hershey, USA. phaouzi@hmc.psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Circulation / physiology* Blood Volume / physiology* Femoral Vein / physiology Regional Blood Flow / physiology Respiratory Physiological Processes* Sheep Vena Cava, Inferior / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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