| Resorptive Hypercalcemia in Post-Essential Thrombocythemia Myelofibrosis: Treatment with Denosumab. | |
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MedLine Citation:
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PMID: 22730513 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Context:Hypercalcemia associated with myelofibrosis is rare, and its pathogenesis and treatment are not known.Objective:We report a unique case of hypercalcemia associated with post-essential thrombocythemia myelofibrosis and review the clinical and laboratory features, pathogenesis, and responsiveness to treatment with the bone antiresorptive agent, denosumab.Results:A 62-yr-old woman with essential thrombocythemia presented with progression to myelofibrosis with lytic skull lesions and symptomatic hypercalcemia. Other causes of hypercalcemia were excluded. Her disturbance in calcium homeostasis was not PTH- or vitamin D-mediated, although this has been postulated in cases of hypercalcemia with the related entity of primary myelofibrosis. Her hypercalcemia was refractory to aggressive iv saline administration, furosemide, calcitonin, and pamidronate, but promptly improved after one 120-mg sc dose of the anti-receptor activator of nuclear factor κB (RANK) ligand monoclonal antibody, denosumab, with sustained normocalcemia for approximately 2 months. She died 6 months later from complications due to the leukemic transformation of her hematological disease.Conclusion:The pathogenesis of myelofibrosis-related hypercalcemia could be due to multiple factors, particularly changes in the RANK ligand-RANK-osteoprotegerin system that lead to increased osteoclast activity. Although we did not measure these factors, denosumab holds promise in the treatment of malignancy-associated hypercalcemia and specifically that related to myelofibrosis. Hypercalcemia associated with myelofibrosis is rare, and its pathogenesis and treatment are not known. |
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Authors:
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Nadia Khoury; Julietta Chang; Alejandro A Gru; Michael P Whyte |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-22 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: - ISSN: 1945-7197 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Endocrinology and Diabetes (N.K.), Medicine (J.C.), and Pathology and Immunology (A.A.G.), and Division of Bone and Mineral Diseases (M.P.W.), Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri 63110; and Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children (M.P.W.), St. Louis, Missouri 63131. |
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