| Resolvins and protectins: natural pharmacophores for resolution biology. | |
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MedLine Citation:
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PMID: 20227865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dietary ingestion of fish is associated with a reduced risk for many common human illnesses. Fish oils are enriched with n-3 polyunsaturated fatty acids eicosapentaenoic acid and docosahexaenoic acid. Resolvins and protectins are newly discovered mediators that are enzymatically generated from these n-3 fatty acid precursors to orchestrate inflammation resolution. These natural compounds and their mimetics are providing intriguing evidence in model systems and translational research for cellular and molecular mechanisms that are active during catabasis. This review provides information on the biosynthesis and actions of these recently identified chemical mediators with particular reference to resolution of mucosal inflammatory responses. |
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Authors:
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Bruce D Levy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-03-15 |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 82 ISSN: 1532-2823 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2010 Apr-Jun |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-08-11 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 327-32 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. BLevy@partners.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, CD59 / chemistry, metabolism* Docosahexaenoic Acids / chemistry, metabolism* Eicosapentaenoic Acid / analogs & derivatives, chemistry, metabolism Humans Inflammation / metabolism Molecular Structure |
| Grant Support | |
ID/Acronym/Agency:
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AI068084/AI/NIAID NIH HHS; P50 DE016191-050004/DE/NIDCR NIH HHS; P50-DE016191/DE/NIDCR NIH HHS; R01 AI068084-04/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid; 0/Antigens, CD59; 0/resolvin D1; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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