Document Detail

Resolving metabolic abnormalities in a case of pure alexia.
MedLine Citation:
PMID:  3258969     Owner:  NLM     Status:  MEDLINE    
We report resolving metabolic abnormalities corresponding to clinical improvement in a patient with pure alexia secondary to acute cerebral infarction. Local cerebral glucose metabolism (lCMRgl) was measured with positron emission tomography (PET) using 18F-fluorodeoxyglucose (18F-FDG) close to ictus and 4 1/2 months later. Serial CTs and a subsequent MRI demonstrated small, unchanging left-hemispheric lesions involving the area of the lateral geniculate body and the splenium of the corpus callosum. PET demonstrated the evolution of the metabolic abnormality resulting from intrahemispheric (lateral geniculate) and interhemispheric (splenium) disconnection in the absence of occipital lobe infarction. This case illustrates that cerebral disconnection can result in the syndrome of pure alexia. The factors accounting for focal hypometabolism in the absence of cerebral infarction are discussed.
F L Silver; J B Chawluk; T M Bosley; M Rosen; R Dann; R C Sergott; A Alavi; M Reivich
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  38     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  730-5     Citation Subset:  AIM; IM    
Department of Neurology, University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Brain / metabolism*
Cerebral Infarction / complications*,  metabolism,  radiography
Dyslexia, Acquired / diagnosis,  metabolism*,  radiography,  radionuclide imaging
Glucose / metabolism*
Magnetic Resonance Imaging
Middle Aged
Tomography, Emission-Computed
Tomography, X-Ray Computed
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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