Document Detail


Resolving a Catch-22 in Cardiac Gene Regulation.
MedLine Citation:
PMID:  22570372     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
"You have a big heart." These five words have almost as many implications. Being "big hearted" can describe a generous and giving nature. In a different context, Secretariat's heart was unusually large because he carried an X-linked gene(1) conferring on him rare physiological attributes that in 1973 propelled him to thoroughbred horse racing's Triple Crown. When the same declaration occurs between cardiologist and patient, however, the connotation is overwhelmingly negative. Heart enlargement from cardiac hypertrophy or dilated cardiomyopathy is a powerful positive predictor of morbidity and mortality(2,3). Accordingly, efforts to more fully understand the molecular underpinnings of structural and functional cardiac remodeling have been a major focus of basic cardiovascular research since genetic reprogramming was first mechanistically linked to cardiac hypertrophy(4,5). Over the past 25 years major transcriptional controls for pathological cardiac gene expression have been defined and suggested novel genetic approaches to control or reverse hypertrophy(6). (SELECT FULL TEXT TO CONTINUE).
Authors:
Gerald W Dorn
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-8
Journal Detail:
Title:  Circulation     Volume:  -     ISSN:  1524-4539     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Washington University School of Medicine, St. Louis, MO.
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