| Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti-VEGF administration. | |
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MedLine Citation:
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PMID: 19657986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Report the resolution of a persistent exudative retinal detachment in a patient with Sturge-Weber syndrome following intravitreal pegaptanib injection. DESIGN: Case report. METHODS: A 13-year-old male with Sturge-Weber syndrome presented with a choroidal hemangioma associated with an exudative retinal detachment that failed to resolve 6 months after external beam radiation therapy. RESULTS: A single intravitreal pegaptanib injection resulted in 50% resolution of the detachment within 1 week and complete resolution within a month. Despite anatomic success, vision remained poor. CONCLUSIONS: VEGF likely plays a role in the pathogenesis of Sturge-Weber choroidal hemangioma-associated exudative retinal detachment and offers potential treatment. |
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Authors:
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Yannis M Paulus; Atul Jain; Darius M Moshfeghi |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ocular immunology and inflammation Volume: 17 ISSN: 1744-5078 ISO Abbreviation: Ocul. Immunol. Inflamm. Publication Date: 2009 Jul-Aug |
Date Detail:
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Created Date: 2009-08-06 Completed Date: 2009-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9312169 Medline TA: Ocul Immunol Inflamm Country: England |
Other Details:
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Languages: eng Pagination: 292-4 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Aptamers, Nucleotide / administration & dosage* Choroid Neoplasms / diagnosis, etiology, radiotherapy Exudates and Transudates / metabolism* Fluorescein Angiography Hemangioma / diagnosis, etiology, radiotherapy Humans Injections Male Retinal Detachment / diagnosis, drug therapy*, etiology*, metabolism Sturge-Weber Syndrome / complications* Treatment Outcome Ultrasonography Vascular Endothelial Growth Factor A / antagonists & inhibitors* Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Aptamers, Nucleotide; 0/Vascular Endothelial Growth Factor A; 0/pegaptanib |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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