Document Detail


Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti-VEGF administration.
MedLine Citation:
PMID:  19657986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Report the resolution of a persistent exudative retinal detachment in a patient with Sturge-Weber syndrome following intravitreal pegaptanib injection. DESIGN: Case report. METHODS: A 13-year-old male with Sturge-Weber syndrome presented with a choroidal hemangioma associated with an exudative retinal detachment that failed to resolve 6 months after external beam radiation therapy. RESULTS: A single intravitreal pegaptanib injection resulted in 50% resolution of the detachment within 1 week and complete resolution within a month. Despite anatomic success, vision remained poor. CONCLUSIONS: VEGF likely plays a role in the pathogenesis of Sturge-Weber choroidal hemangioma-associated exudative retinal detachment and offers potential treatment.
Authors:
Yannis M Paulus; Atul Jain; Darius M Moshfeghi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ocular immunology and inflammation     Volume:  17     ISSN:  1744-5078     ISO Abbreviation:  Ocul. Immunol. Inflamm.     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312169     Medline TA:  Ocul Immunol Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  292-4     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Stanford University School of Medicine, Stanford, California 94305, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aptamers, Nucleotide / administration & dosage*
Choroid Neoplasms / diagnosis,  etiology,  radiotherapy
Exudates and Transudates / metabolism*
Fluorescein Angiography
Hemangioma / diagnosis,  etiology,  radiotherapy
Humans
Injections
Male
Retinal Detachment / diagnosis,  drug therapy*,  etiology*,  metabolism
Sturge-Weber Syndrome / complications*
Treatment Outcome
Ultrasonography
Vascular Endothelial Growth Factor A / antagonists & inhibitors*
Vitreous Body
Chemical
Reg. No./Substance:
0/Aptamers, Nucleotide; 0/Vascular Endothelial Growth Factor A; 0/pegaptanib

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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