Document Detail

Resolution of pain and complete healing of mandibular osteoradionecrosis using pentoxifylline and tocopherol: a case report.
MedLine Citation:
PMID:  22668439     Owner:  NLM     Status:  In-Data-Review    
The radiation-induced fibroatrophic process (RIF) is a time-dependent adverse sequela to high-dose radiotherapy that can result in irreversible tissue death and bone exposure in the irradiated tissue. Osteoradionecrosis (ORN) is a late effect of RIF, described as bony exposure present for more than 3 months that can occur in 20% of patients irradiated for head and neck cancer. The intractable characteristics of ORN make both management and resolution of the disease process challenging, with 25% of cases recurring despite aggressive treatment with resection and reconstruction of the necrotic bone. In this article, we present a case of a 66-year-old man with unevoked ORN of the left posterior lingual mandibular cortex that was successfully treated and resolved with 6 months of pentoxifylline 400 mg twice a day and tocopherol 1000 IU every day.
Nora Kahenasa; Eric C Sung; Vishad Nabili; Jim Kelly; Neal Garrett; Ichiro Nishimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oral surgery, oral medicine, oral pathology and oral radiology     Volume:  113     ISSN:  2212-4411     ISO Abbreviation:  Oral Surg Oral Med Oral Pathol Oral Radiol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-06-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576782     Medline TA:  Oral Surg Oral Med Oral Pathol Oral Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e18-23     Citation Subset:  D; IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Section of Oral & Maxillofacial Surgery, University of California, Los Angeles, School of Dentistry, Los Angeles, California; Weintraub Center for Reconstructive Biotechnology, University of California, Los Angeles, School of Dentistry, Los Angeles, California.
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