| Resolution of the neutropenia of Felty's syndrome by longterm administration of recombinant granulocyte colony stimulating factor. | |
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MedLine Citation:
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PMID: 8730142 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Felty's syndrome is characterized by neutropenia, splenomegaly, and recurrent infection in patients with rheumatoid arthritis. We used recombinant granulocyte colony stimulating factor (rGCSF) in a patient with Felty's syndrome and recurrent sepsis. rGCSF induced a statistically significant increase in the patient's absolute neutrophil and total white blood cell counts. During 14 months of followup taking rGCSF, disseminated varicella zoster was the only infectious complication. Except mild thrombocytopenia and a transient flare of arthritis, no serious adverse effects occurred. rGCSF may be a safe and effective therapy for Felty's syndrome in selected patients. |
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Authors:
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G Krishnaswamy; C Odem; D S Chi; J Kalbfleisch; N Baker; J K Smith |
Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: The Journal of rheumatology Volume: 23 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-09-25 Completed Date: 1996-09-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 763-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, East Tennessee State University, James H. Quillen College of Medicine, Johnson City 37614-0622, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bacteremia / complications Felty's Syndrome / blood, complications, drug therapy* Follow-Up Studies Granulocyte Colony-Stimulating Factor / administration & dosage*, therapeutic use Herpes Zoster / complications Humans Leukocyte Count Male Neutropenia / blood, complications, drug therapy* Neutrophils / immunology* Recombinant Proteins / administration & dosage, therapeutic use Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Recombinant Proteins; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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