| Resolution of microsporidial sinusitis and keratoconjunctivitis by itraconazole treatment. | |
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MedLine Citation:
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PMID: 10030568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report successful treatment of ocular infection caused by the microsporidium Encephalitozoon cuniculi in a person with acquired immunodeficiency syndrome (AIDS) and nasal and paranasal sinus infection. METHOD: Case report. RESULTS: Microsporidial infection in a person with AIDS and with chronic sinusitis and keratoconjunctivitis was diagnosed by Weber modified trichrome stain and transmission electron microscopy. Symptoms completely resolved with itraconazole treatment (200 mg/day for 8 weeks) after albendazole therapy (400 mg/day for 6 weeks) was unsuccessful. CONCLUSION: Itraconazole can be recommended in ocular, nasal, and paranasal sinus infection caused by E. cuniculi parasites when treatment with albendazole fails. |
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Authors:
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P Rossi; C Urbani; G Donelli; E Pozio |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 127 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 210-2 Citation Subset: AIM; IM; X |
Affiliation:
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Laboratory of Parasitology, Istituto Superiore di Sanità, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy,
parasitology Adult Animals Antifungal Agents / therapeutic use* Encephalitozoon cuniculi / isolation & purification*, ultrastructure Encephalitozoonosis / drug therapy*, parasitology Epithelium, Corneal / parasitology Eye Infections, Parasitic / drug therapy*, parasitology Humans Itraconazole / therapeutic use* Keratoconjunctivitis / drug therapy*, parasitology Male Sinusitis / drug therapy*, parasitology |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 84625-61-6/Itraconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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