Document Detail

Resolution of flecainide acetate, N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzam ide acetate, and antiarrhythmic properties of the enantiomers.
MedLine Citation:
PMID:  3950909     Owner:  NLM     Status:  MEDLINE    
The antiarrhythmic agent flecainide acetate was resolved by fractional crystallization of its diastereomeric alpha-bromocamphor-pi-sulfonate salts. Optical purity of the two enantiomers was shown to be greater than 99% by an NMR technique using the chiral shift reagent Eu(hfbc)3. Antiarrhythmic effects of flecainide and its enantiomers were assessed in two different animal models, chloroform-induced ventricular fibrillation in mice and ouabain-induced ventricular tachycardia in dogs. The two enantiomers were highly effective in suppressing both of these experimental arrhythmias and appeared to be essentially equipotent. No significant differences were found either between the two enantiomers or between the enantiomers and racemic flecainide.
E H Banitt; J R Schmid; R A Newmark
Related Documents :
25488019 - The spatial distribution of actin and mechanical cycle of myosin are different in right...
9622939 - Anatomical and microstructural factors affecting the electrical activity of the heart. ...
25236259 - Electrocardiogram characteristics prior to in-hospital cardiac arrest.
25334079 - Slowed intrinsic heart rate is associated with reduced arrhythmic susceptibility in gui...
25310909 - Cardioprotective effects of oxymatrine on isoproterenol-induced heart failure via regul...
25331159 - Hold or fold - proteins in advanced heart failure and myocardial recovery.
7203929 - Cardiovascular radiology. cardiac alterations during intravenous urography.
3409899 - Left atrial ball thrombus: echocardiographic features and clinical implications.
11136349 - Transcranial colour-coded sonography for the bedside evaluation of mass effect after st...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  29     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-03-28     Completed Date:  1986-03-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Arrhythmia Agents / pharmacology*
Magnetic Resonance Spectroscopy
Piperidines / pharmacology*
Tachycardia / drug therapy
Ventricular Fibrillation / drug therapy
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Piperidines; 54143-55-4/Flecainide; 630-60-4/Ouabain; 67-66-3/Chloroform

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synthesis and biological activity of certain nucleoside and nucleotide derivatives of pyrazofurin.
Next Document:  Synthesis and evaluation of 2,3-dihydrobenzofuran analogues of the hallucinogen 1-(2,5-dimethoxy-4-m...