Document Detail

Resolution of adipose tissue inflammation.
MedLine Citation:
PMID:  20454765     Owner:  NLM     Status:  MEDLINE    
The presence of the so-called "low-grade" inflammatory state is recognized as a critical event in adipose tissue dysfunction in obesity. This chronic "low-grade" inflammation in white adipose tissue is powerfully augmented through the infiltration of macrophages, which, together with adipocytes, perpetuate a vicious cycle of macrophage recruitment and secretion of free fatty acids and deleterious adipokines that predispose the development of obesity-related comorbidities, such as insulin resistance and nonalcoholic fatty liver disease. In the last decade, many factors have been identified that contribute to mounting uncontrolled inflammation in obese adipose tissue. Among them, bioactive lipid mediators derived from the cyclooxygenase and 5-lipoxygenase pathways, which convert the omega-6-polyunsaturated fatty acid (PUFA) arachidonic acid into potent proinflammatory eicosanoids (i.e., prostaglandins [PGs] and leukotrienes), have emerged. Interestingly, the same lipid mediators that initially trigger the inflammatory response also signal the termination of inflammation by stimulating the biosynthesis of anti-inflammatory and proresolving lipid autacoids. This review discusses the current status, characteristics, and progress in this class of "stop signals", including the lipoxins, which were the first identified omega-6 PUFA-derived lipid mediators with potent anti-inflammatory properties; the recently described omega-3 PUFA-derived lipid mediators resolvins and protectins; and the cyclopentenone PGs of the D series. Special emphasis is given to the participation of these bioactive lipid autacoids in the resolution of adipose tissue inflammation and in preventing the development of obesity-related complications.
Ana González-Périz; Joan Clària
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-04
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  10     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  832-56     Citation Subset:  IM    
Department of Biochemistry and Molecular Genetics, Hospital Clinic, IDIBAPS, CIBEK, CIBERehd, University of Barcelona.
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MeSH Terms
Adipokines / physiology
Adipose Tissue / pathology*
Fatty Acids, Omega-3 / pharmacology*
Fatty Acids, Omega-6 / pharmacology*
Inflammation / pathology,  prevention & control*
Reg. No./Substance:
0/Adipokines; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6

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