| Resolution of Behçet's Syndrome Associated Pulmonary Arterial Aneurysms with Infliximab. | |
| | |
MedLine Citation:
|
PMID: 21546064 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION: We describe the successful treatment of pulmonary arterial aneurysms in Behçet's syndrome using a tumor necrosis factor (TNF) inhibitor. METHODS: A case is reported of Behçet's syndrome complicated by pulmonary arterial aneurysms that responded to anti-TNF therapy. This is accompanied by a literature review of previously published cases. We searched the English language medical literature using the PubMed and Medline search terms: "Behçet's," "Pulmonary aneurysms," and "infliximab," "etanercept," or "adalimumab." RESULTS: A 43-year-old man with a 6-month history of oral and genital ulcers, weight loss, and fatigue developed arterial aneurysms in the common carotid and common iliac arteries and thromboses in a femoral vein and pulmonary arteries. Treatment with high-dose oral corticosteroids and pulsed intravenous cyclophosphamide was initiated but while on treatment he developed pulmonary arterial aneurysms with hemoptysis. His treatment was changed to intravenous infliximab with methotrexate to which he showed a good response with marked clinical improvement, reduction in his inflammatory markers, and regression of the pulmonary arterial aneurysms. The review of the literature identified 3 reported cases of treatment of pulmonary arterial aneurysms in Behçet's syndrome with anti-TNF therapy, with good outcomes in each case. CONCLUSIONS: Pulmonary artery aneurysms are important complications of Behçet's syndrome. Anti-TNF inhibitors should be considered in patients who do not respond to treatment with corticosteroids and cyclophosphamide. |
| | |
Authors:
|
Benjamin E Schreiber; Nadim Noor; Christoph F Juli; Dorian O Haskard |
Related Documents
:
|
21162774 - Endovascular embolization of distal anterior choroidal artery aneurysms associated with... 9732544 - Interventional neuroradiology. 563534 - Narrowing and occlusion of arteries by intracranial tumors. review of the literature an... 21550314 - Influence of sex on outcomes of stenting versus endarterectomy: a subgroup analysis of ... 3519224 - Evaluation of total anomalous pulmonary venous drainage with cross-sectional colour-flo... 19117724 - Pseudo-pericardial tamponade after cardiac surgery. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: Seminars in arthritis and rheumatism Volume: - ISSN: 1532-866X ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1306053 Medline TA: Semin Arthritis Rheum Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Royal Free Hampstead NHS Trust, London, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Population-Based Normative Values for the Australian/Canadian (AUSCAN) Hand Osteoarthritis Index: Pa...
Next Document: Population-Based Normative Values for the Western Ontario and McMaster (WOMAC) Osteoarthritis Index:...