Document Detail


Resolution of Lyme arthritis, acute or prolonged: a new look.
MedLine Citation:
PMID:  11128048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
I have presented a paradigm for the pathogenesis and resolution of Lyme arthritis founded upon the clinical facts that describe its natural history, and centered about a process of intermittent immune recognition of what may sometimes be an array of antigenic variants. The model applies both to acute and to prolonged (chronic) disease. If it proves to be correct, it represents a variation of the struggle between parasite and host that is probably not limited to Lyme disease.
Authors:
S E Malawista
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Inflammation     Volume:  24     ISSN:  0360-3997     ISO Abbreviation:  Inflammation     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-02-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600105     Medline TA:  Inflammation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  493-504     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Yale University School at Medicine, New Haven, Connecticut, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Antigens / genetics
Autoimmunity
Chronic Disease
Genetic Variation
Humans
Lyme Disease / immunology,  physiopathology*,  therapy
Grant Support
ID/Acronym/Agency:
AI-43558/AI/NIAID NIH HHS; AR-10493/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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