| Resolution of Headache and Papilledema in Idiopathic Intracranial Hypertension Associated With Inhibition of Na+-K+-2Cl- Cotransport. | |
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MedLine Citation:
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PMID: 21285039 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Medical treatment of idiopathic intracranial hypertension is often ineffective. Cerebrospinal fluid diversion or optic nerve sheath fenestration is employed when medical therapy fails. Here, we describe a case of a 13-year-old girl with idiopathic intracranial hypertension refractory to long-term trials of acetazolamide and furosemide at maximally tolerated doses. After declining surgical intervention despite progression of her visual symptoms, a trial of bumetanide (0.25 mg daily) monotherapy was successful in resolution of the patient's symptoms. These results suggest bumetanide could be effective in the treatment of idiopathic intracranial hypertension, perhaps by restoring the balance between cerebrospinal fluid formation and absorption and/or by altering the volume or ionic composition of the brain's extracellular fluid compartment. |
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Authors:
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Kristopher T Kahle; Brian P Walcott; Kevin J Staley |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 26 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 205-8 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA. kstaley@partners.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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