Document Detail


Resolution of Diabetes After Pancreaticoduodenectomy in Patients with and without Pancreatic Ductal Cell Adenocarcinoma.
MedLine Citation:
PMID:  22864799     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: New-onset diabetes mellitus (DM) is associated with pancreatic ductal cell adenocarcinoma (PDCA) and can resolve after pancreaticoduodenectomy (PD). Whether DM also resolves after PD in patients operated for disease other than PDCA remains to be determined. METHODS: We compared glycemic status before and after PD between patients with and without PDCA by review of a prospectively maintained database including all patients receiving PD from 2005 to 2011. New-onset DM was defined as diagnosis of DM less than 24 months before PD, and cases with DM diagnosis ≥24 months preceding PD were described as long-standing DM. RESULTS: Of 458 patients receiving PD, there were 146 (31.9 %) PDCA and 312 (68.1 %) non-PDCA, including 160 benign diseases, 113 ampulla cancer, 29 distal common bile duct cancer, and 10 duodenal cancer. Overall prevalence of DM was higher in PDCA group than non-PDCA group (37.7 vs. 25.6 %; P = 0.011). Resolution of new-onset DM after PD was observed in 9 (41 %) of 22 patients with PDCA and in 12 (63 %) of 19 patients without PDCA. Resolution of long-standing DM after PD was also observed in 3 (9.1 %) of 33 patients with PDCA and in 6 (9.8 %) of 61 patients without PDCA. CONCLUSIONS: DM resolved after PD in some patients both with and without PDCA. These findings suggest that PD-associated anatomic change may play a role in resolution of DM after PD.
Authors:
Jin-Ming Wu; Ting-Chun Kuo; Ching-Yao Yang; Pin-Yi Chiang; Yung-Ming Jeng; Pei-Hsin Huang; Yu-Wen Tien
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-3
Journal Detail:
Title:  Annals of surgical oncology     Volume:  -     ISSN:  1534-4681     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, ROC.
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