| Resistin, exercise capacity, and inducible ischemia in patients with stable coronary heart disease: data from the Heart and Soul study. | |
| | |
MedLine Citation:
|
PMID: 20951381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Resistin is an adipocytokine involved in insulin resistance, inflammation, and atherosclerosis. Its role in the development and progression of coronary heart disease (CHD) is not yet well-characterized. We performed a cross-sectional study to evaluate the association between serum resistin levels, exercise capacity, and exercise-induced cardiac ischemia among patients with stable CHD. METHODS AND RESULTS: We measured serum resistin concentrations and determined treadmill exercise capacity and inducible ischemia by stress echocardiography in 899 outpatients with documented CHD. Of these, 215 (24%) had poor exercise capacity (<5 metabolic equivalent tasks), and 217 (24%) had inducible ischemia. As compared with participants who had resistin levels in the lowest quartile, those with resistin levels in the highest quartile were more likely to have poor exercise capacity (33% versus 16%, odds ratio [OR] 2.68, P<0.0001) and inducible ischemia (30% versus 17%, OR 2.08, P=0.001). Both associations remained robust after adjusting for numerous clinical risk factors, metabolic variables, and markers of insulin resistance (poor exercise capacity adjusted OR 1.73, P=0.04; inducible ischemia adjusted OR 1.82, P=0.01). However, further adjustments for C-reactive protein, interleukin-6, and tumor necrosis factor-α eliminated the association with poor exercise capacity (adjusted OR 1.50, P=0.14) and substantially weakened the association with inducible ischemia (adjusted OR 1.72, P=0.03). CONCLUSIONS: Elevated serum resistin is associated with poor exercise capacity and exercise-induced cardiac ischemia in patients with stable coronary disease. Adjustment for inflammatory markers attenuated these associations, suggesting a possible role for resistin in inflammation and CHD pathophysiology. |
| | |
Authors:
|
Mary H Zhang; Beeya Na; Nelson B Schiller; Mary A Whooley |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-09-24 |
Journal Detail:
|
Title: Atherosclerosis Volume: 213 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-06 Completed Date: 2011-03-18 Revised Date: 2011-11-04 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 604-10 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ireland Ltd. |
Affiliation:
|
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged C-Reactive Protein / metabolism Coronary Disease / blood, physiopathology* Cross-Sectional Studies Echocardiography, Stress Exercise Test* Female Humans Interleukin-6 / blood Male Middle Aged Myocardial Ischemia / blood*, etiology Resistin / blood* Tumor Necrosis Factor-alpha / blood |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HL079235/HL/NHLBI NIH HHS; R01 HL079235-01A1/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6; 0/Resistin; 0/Tumor Necrosis Factor-alpha; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of coronary plaque characteristics by optical coherence tomography in patients with diabe...
Next Document: 'Contributions of individual muscles to hip joint contact force in normal walking' by T.A. Correa, K...