| Resistin contributes to neointimal formation via oxidative stress after vascular injury. | |
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MedLine Citation:
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PMID: 20795947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resistin may play a major potential role in vascular remodelling and may contribute to atherogenesis. However, the role of VSMC (vascular smooth muscle cell)-derived resistin in neointimal formation is not well understood. We hypothesize that endogenous resistin derived from VSMCs may contribute to neointimal formation after vascular injury. VSMCs from thoracic aorta of adult Wistar rats were cultured. The carotid artery from adult Wistar rats was injured by balloon catheter. Resistin significantly increased migration and proliferation of VSMCs. Resistin siRNA (small interfering RNA) and resistin antibody significantly inhibited migration and proliferation of VSMCs induced by conditioned medium from stretched VSMCs. Resistin protein and mRNA expression significantly increased at 14 days after carotid injury. Resistin siRNA and NAC (N-acetylcysteine) significantly reduced resistin protein and mRNA expression induced by balloon injury. Carotid artery injury increased ROS (reactive oxygen species) production. Treatment with NAC and resistin siRNA decreased ROS production. The neointimal area was significantly increased after carotid injury and was significantly reduced by resistin siRNA and NAC. In conclusion, resistin increases migration and proliferation of VSMCs, and expression of resistin in carotid artery significantly increases after injury. Resistin siRNA attenuates neointimal formation after carotid injury partly through an antioxidative mechanism. Resistin may play a pivotal role in the pathogenesis of neointimal thickening after mechanical injury. |
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Authors:
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Kou-Gi Shyu; Li-Ming Lien; Bao-Wei Wang; Peiliang Kuan; Hang Chang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 120 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 121-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Thoracic / metabolism, pathology Carotid Artery Injuries / metabolism*, pathology Cell Movement / physiology Cell Proliferation Cells, Cultured Culture Media, Conditioned Gene Expression Regulation Muscle, Smooth, Vascular / metabolism*, pathology Oxidative Stress / physiology* RNA Interference RNA, Messenger / genetics RNA, Small Interfering / genetics Rats Rats, Wistar Reactive Oxygen Species / metabolism Resistin / genetics, physiology* Tunica Intima / metabolism, pathology Tunica Media / metabolism, pathology |
| Chemical | |
Reg. No./Substance:
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0/Culture Media, Conditioned; 0/RNA, Messenger; 0/RNA, Small Interfering; 0/Reactive Oxygen Species; 0/Resistin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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