Document Detail

Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
MedLine Citation:
PMID:  19245965     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We tested the association of the adipokines resistin and adiponectin with incident heart failure.
BACKGROUND: Abnormal concentrations of adipokines may partially explain the association between obesity and heart failure.
METHODS: We related circulating adipokine concentrations to the incidence of heart failure in 2,739 participants in the Framingham Offspring Study.
RESULTS: During 6 years of follow-up, 58 participants developed new-onset heart failure. In proportional hazards models (adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/high-density lipoprotein cholesterol ratio, prevalent coronary heart disease, valvular heart disease, left ventricular hypertrophy, and estimated glomerular filtration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios for heart failure in the middle and top thirds were 2.89 (95% confidence interval [CI]: 1.05 to 7.92) and 4.01 (95% CI: 1.52 to 10.57), respectively (p = 0.004 for trend). Additional adjustment for body mass index, insulin resistance (measured with the homeostasis model), C-reactive protein, and B-type natriuretic peptide did not substantively weaken this association (multivariable hazard ratios [HRs]: 2.62 and 3.74, p = 0.007). In the maximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase in heart failure risk (95% CI: 1% to 60%). Concentrations of adiponectin were not associated with heart failure (multivariable HRs: 0.87 and 0.97, p = 0.9).
CONCLUSIONS: Increased circulating concentrations of resistin were associated with incident heart failure, even after accounting for prevalent coronary heart disease, obesity, and measures of insulin resistance and inflammation. The findings suggest a role for resistin in human disease and a novel pathway to heart failure.
David S Frankel; Ramachandran S Vasan; Ralph B D'Agostino; Emelia J Benjamin; Daniel Levy; Thomas J Wang; James B Meigs
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-12-26
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  53     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-27     Completed Date:  2009-03-27     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  754-62     Citation Subset:  AIM; IM    
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MeSH Terms
Adiponectin / blood*
Adult Children
Biological Markers / blood
C-Reactive Protein / metabolism
Confidence Intervals
Exercise Tolerance
Heart Failure / blood*,  epidemiology,  physiopathology
Inflammation / blood
Insulin Resistance
Massachusetts / epidemiology
Middle Aged
Natriuretic Peptide, Brain / blood
Obesity / blood*,  physiopathology
Predictive Value of Tests
Prospective Studies
Resistin / blood*
Risk Factors
United States / epidemiology
Grant Support
1R01 AG028321/AG/NIA NIH HHS; 2K24HL404334/HL/NHLBI NIH HHS; K24 DK080140/DK/NIDDK NIH HHS; K24 DK080140-01/DK/NIDDK NIH HHS; K24 DK080140-02/DK/NIDDK NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Resistin; 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein
Comment In:
J Am Coll Cardiol. 2009 Mar 3;53(9):763-4   [PMID:  19245966 ]

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