| Resistin, adiponectin, and risk of heart failure the Framingham offspring study. | |
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MedLine Citation:
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PMID: 19245965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We tested the association of the adipokines resistin and adiponectin with incident heart failure. BACKGROUND: Abnormal concentrations of adipokines may partially explain the association between obesity and heart failure. METHODS: We related circulating adipokine concentrations to the incidence of heart failure in 2,739 participants in the Framingham Offspring Study. RESULTS: During 6 years of follow-up, 58 participants developed new-onset heart failure. In proportional hazards models (adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/high-density lipoprotein cholesterol ratio, prevalent coronary heart disease, valvular heart disease, left ventricular hypertrophy, and estimated glomerular filtration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios for heart failure in the middle and top thirds were 2.89 (95% confidence interval [CI]: 1.05 to 7.92) and 4.01 (95% CI: 1.52 to 10.57), respectively (p = 0.004 for trend). Additional adjustment for body mass index, insulin resistance (measured with the homeostasis model), C-reactive protein, and B-type natriuretic peptide did not substantively weaken this association (multivariable hazard ratios [HRs]: 2.62 and 3.74, p = 0.007). In the maximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase in heart failure risk (95% CI: 1% to 60%). Concentrations of adiponectin were not associated with heart failure (multivariable HRs: 0.87 and 0.97, p = 0.9). CONCLUSIONS: Increased circulating concentrations of resistin were associated with incident heart failure, even after accounting for prevalent coronary heart disease, obesity, and measures of insulin resistance and inflammation. The findings suggest a role for resistin in human disease and a novel pathway to heart failure. |
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Authors:
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David S Frankel; Ramachandran S Vasan; Ralph B D'Agostino; Emelia J Benjamin; Daniel Levy; Thomas J Wang; James B Meigs |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-12-26 |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 53 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-27 Completed Date: 2009-03-27 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 754-62 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiponectin
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blood* Adult Children Biological Markers / blood C-Reactive Protein / metabolism Confidence Intervals Exercise Tolerance Female Heart Failure / blood*, epidemiology, physiopathology Humans Inflammation / blood Insulin Resistance Male Massachusetts / epidemiology Middle Aged Natriuretic Peptide, Brain / blood Obesity / blood*, physiopathology Predictive Value of Tests Prospective Studies Resistin / blood* Risk Factors United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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1R01 AG028321/AG/NIA NIH HHS; 2K24HL404334/HL/NHLBI NIH HHS; K24 DK080140-01/DK/NIDDK NIH HHS; K24 DK080140-02/DK/NIDDK NIH HHS; K24 DK080140-05/DK/NIDDK NIH HHS; N01-HC-25195/HC/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adiponectin; 0/Biological Markers; 0/Resistin; 114471-18-0/Natriuretic Peptide, Brain; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2009 Mar 3;53(9):763-4
[PMID:
19245966
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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