| Resistin Is an Indicator of the Metabolic Syndrome According to Five Different Definitions in the Finnish Health 2000 Survey. | |
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MedLine Citation:
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PMID: 21332410 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the association of resistin with metabolic syndrome and its components in a population-based cohort. Methods: A subsample of a large Finnish cross-sectional health examination survey (the Health 2000 Survey) was studied. Resistin was measured using an in-house assay based on the DELFIA(®) technique in 1,508 Finnish men and women aged 45-74 years. Metabolic syndrome was defined according to five different definitions. Results: Resistin levels were higher in the subjects with metabolic syndrome when compared to the subjects without metabolic syndrome (P < 0.05 for every metabolic syndrome criterion). In logistic regression analysis, a high resistin level was an independent predictor of the prevalence of metabolic syndrome (P < 0.05 for every criterion). Resistin was positively associated with waist circumference, tumor necrosis factor-α, and insulin resistance assessed by the homeostasis model and inversely with total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after adjusting for age, gender, and body mass index (P < 0.05 for all). Conclusions: These results clarify the controversial association of resistin in obesity and metabolic syndrome, suggesting that a high resistin level is associated with clustering of metabolic disturbances. |
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Authors:
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Elina Malo; Olavi Ukkola; Maarit Jokela; Leena Moilanen; Mika Kähönen; Markku S Nieminen; Veikko Salomaa; Antti Jula; Y Antero Kesäniemi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-20 |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: - ISSN: 1557-8518 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center , Oulu University Hospital, Oulu, Finland . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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