| Resistant starch decreases serum total cholesterol and triacylglycerol concentrations in rats. | |
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MedLine Citation:
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PMID: 8263609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were meal-fed semipurified diets containing a low (0.8 g/MJ) and a high (9.6 g/MJ) amount of resistant starch (RS) or various amounts of RS (0.8 to 9.6 g/MJ) and guar gum (0 to 8.8 g/MJ). In one experiment, rats were fed the low and high RS diets in three dietary regimens (ad libitum consuming, 12 h ad libitum/12 h food deprived, and meal fed). Effects of RS and guar gum on serum postprandial and postabsorptive concentrations of total cholesterol (TC) and triacylglycerol (TAG), growth, hydrogen excretion, tissue weights and contents of small intestine and cecum, and pH of cecal contents were investigated. In addition, effects of RS on food intake, de novo hepatic synthesis of fatty acids and neutral sterols, and on lipoprotein lipase activity and weight of epididymal fat pads were investigated. Compared with feeding the low RS diet, the high RS diet reduced the serum TC and TAG concentrations, with these effects observed after 1 and 2 wk of feeding, respectively. The dietary regimen did not influence the effect of RS on the serum TC and TAG concentrations, but it did affect the serum TAG concentration. Resistant starch had no effect on the hepatic synthesis of fatty acids and neutral sterols or on the lipoprotein lipase activity in epididymal fat pads. Guar gum also reduced the serum TC concentration, but it had no effect on serum TAG concentration. The tissue weights and contents of small intestine and cecum as well as hydrogen excretion increased with increasing amounts of dietary RS and guar gum, whereas the pH of cecal contents decreased. No effects of RS on food intake and total body weight gain were found, whereas guar gum decreased weight gain. Feeding the high RS diet also led to a lower weight of the epididymal fat pads. We conclude that dietary RS can reduce serum TC and TAG concentrations and fat accretion. |
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Authors:
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E A de Deckere; W J Kloots; J M van Amelsvoort |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 123 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-01-24 Completed Date: 1994-01-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2142-51 Citation Subset: IM |
Affiliation:
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Unilever Research Laboratorium Vlaardingen, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cecum / anatomy & histology, chemistry Cholesterol / biosynthesis, blood* Dietary Carbohydrates / administration & dosage, metabolism* Dietary Fiber Digestion Eating Epididymis / enzymology Fatty Acids / biosynthesis Galactans / administration & dosage, metabolism Hydrogen / urine Hydrogen-Ion Concentration Intestine, Small / anatomy & histology, chemistry Lipoprotein Lipase / metabolism Liver / metabolism Male Mannans / administration & dosage, metabolism Organ Size Plant Gums Rats Rats, Wistar Regression Analysis Starch / administration & dosage, metabolism* Sterols / biosynthesis Triglycerides / blood* Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Fatty Acids; 0/Galactans; 0/Mannans; 0/Plant Gums; 0/Sterols; 0/Triglycerides; 1333-74-0/Hydrogen; 57-88-5/Cholesterol; 9000-30-0/guar gum; 9005-25-8/Starch; EC 3.1.1.34/Lipoprotein Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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