| Resistant or difficult-to-treat hypertension. | |
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MedLine Citation:
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PMID: 16522995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Resistant hypertension, defined as uncontrolled hypertension on three medications, is becoming an increasingly common problem. In most cases, blood pressure remains elevated because of persistently high systolic blood pressure levels. Common characteristics of patients with resistant hypertension include older age, obesity, excessive dietary salt ingestion, and presence of sleep apnea. The evaluation of patients with resistant hypertension is focused on identifying contributing and secondary causes of hypertension. Treatment should include both lifestyle changes (weight loss, exercise, dietary salt restriction) and the use of effective multidrug regimens, including a diuretic. Recent data indicate that aldosterone antagonists may be effective when added to existing antihypertensive regimens even in the absence of primary aldosteronism. |
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Authors:
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David A Calhoun |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Journal of clinical hypertension (Greenwich, Conn.) Volume: 8 ISSN: 1524-6175 ISO Abbreviation: J Clin Hypertens (Greenwich) Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-08 Completed Date: 2006-06-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100888554 Medline TA: J Clin Hypertens (Greenwich) Country: United States |
Other Details:
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Languages: eng Pagination: 181-6 Citation Subset: IM |
Affiliation:
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Vascular Biology and Hypertension Program, Center for Sleep/Wake Disorders, University of Alabama at Birmingham, Birmingham, AL 35294, USA. dcalhoun@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Drinking
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adverse effects Antihypertensive Agents / therapeutic use* Drug Interactions Humans Hypertension / drug therapy*, therapy Life Style Obesity / complications Sleep Apnea, Obstructive / complications Sodium, Dietary / adverse effects Treatment Failure* |
| Grant Support | |
ID/Acronym/Agency:
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HL075614/HL/NHLBI NIH HHS; P50HL077100/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Sodium, Dietary |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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