Document Detail

Resistance training to reduce the malnutrition-inflammation complex syndrome of chronic kidney disease.
MedLine Citation:
PMID:  15042537     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Systemic inflammation and protein-energy malnutrition may be associated with poor outcomes in kidney disease. METHODS: We studied 26 adults (age, 65 +/- 10 [SD] years) with chronic kidney disease, not on dialysis therapy. Subjects were randomly assigned to resistance training (n = 14) or a control group (n = 12) for 12 weeks, while counseled to consume a low-protein diet (protein, approximately 0.6 g/kg/d). We determined whether resistance training reduces levels of inflammatory mediators (serum C-reactive protein [CRP] and interleukin-6 [IL-6]), in addition to previously reported improvements in nutritional and functional status in this same subject population. RESULTS: Serum CRP levels were reduced in subjects undergoing resistance training (-1.7 mg/L) compared with controls (1.5 mg/L; P = 0.05). Similarly, IL-6 levels were reduced in the resistance-exercise group versus controls (-4.2 versus 2.3 pg/mL; P = 0.01). Resistance training lead to skeletal muscle hypertrophy, shown by increases in type I (24% +/- 31%) and type II (22% +/- 41%) muscle fiber cross-sectional areas, compared with control subjects (-14% +/- 34% and -13% +/- 18%, respectively; P < 0.05). Muscle strength also improved with resistance training (28% +/- 14%) compared with controls (-13% +/- 22%; P = 0.001). CONCLUSION: Resistance training reduced inflammation and improved nutritional status in individuals with moderate chronic kidney disease consuming a low-protein diet. These results need to be investigated further in larger cohorts of patients with varying stages of kidney disease to determine whether resistance training can improve disease outcomes long term.
Carmen Castaneda; Patricia L Gordon; Russell C Parker; Katherine Leigh Uhlin; Ronenn Roubenoff; Andrew S Levey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  43     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-06-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  607-16     Citation Subset:  IM    
Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
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MeSH Terms
C-Reactive Protein / metabolism
Diet, Protein-Restricted
Exercise Therapy*
Inflammation / etiology*,  prevention & control
Inflammation Mediators / blood*
Interleukin-6 / blood
Kidney Failure, Chronic / physiopathology*,  therapy*
Middle Aged
Nutritional Status
Protein-Energy Malnutrition / etiology*,  prevention & control*
Grant Support
Reg. No./Substance:
0/Inflammation Mediators; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

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