Document Detail


Resistance training increases SHBG in overweight/obese, young men.
MedLine Citation:
PMID:  23318050     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Evidence suggests that SHBG affects glycemic control, predicts both T2D and metabolic syndrome, and is low in obese subjects. We sought to determine if resistance exercise training (RT) can increase sex hormone-binding globulin (SHBG) and ameliorate levels of related steroid hormones in overweight/obese, sedentary young men.
MATERIALS/METHODS: 36 participants (BMI 31.4 kg/m(2), age 22 years) were randomized into an RT (12 weeks of training, 3/week) or control group (C, 12 weeks no training), and assessed for changes in SHBG, cortisol, testosterone, free testosterone (FT) and free androgen index (FAI). In addition, body composition and oral glucose tolerance testing was performed.
RESULTS: 12 weeks of RT increased SHBG (P=0.01) and decreased FAI (P<0.05) and cortisol (P<0.05) compared to C. FT decreased in RT (P=0.01). Total testosterone did not change in either group. These changes were noted without weight loss, and in concert with increases in lean body mass (P=0.0002 vs C) and decreases in glucose area under the curve (AUC) (P=0.004), insulin AUC (P=0.03), and total (P=0.002) and trunk (P=0.003) fat mass in RT.
CONCLUSION: In overweight/obese young men, RT increases SHBG and lowers FAI in obese young adult men.
Authors:
Christian K Roberts; Daniel M Croymans; Najib Aziz; Anthony W Butch; Cathy C Lee
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-12
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  62     ISSN:  1532-8600     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-22     Completed Date:  2013-06-26     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  United States    
Other Details:
Languages:  eng     Pagination:  725-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Algorithms
Body Composition / physiology
Humans
Male
Muscle Strength / physiology
Obesity / blood*,  metabolism,  therapy
Overweight / blood*,  metabolism,  therapy
Resistance Training*
Sex Factors
Sex Hormone-Binding Globulin / analysis,  metabolism*
Testosterone / blood,  metabolism
Up-Regulation
Young Adult
Grant Support
ID/Acronym/Agency:
DK090406/DK/NIDDK NIH HHS; P50 HL105188/HL/NHLBI NIH HHS; UL1 TR000124/TR/NCATS NIH HHS; UL1TR000124/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Sex Hormone-Binding Globulin; 3XMK78S47O/Testosterone
Comments/Corrections

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