| Resistance training alters the response of fed state mixed muscle protein synthesis in young men. | |
| | |
MedLine Citation:
|
PMID: 18032468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ten healthy young men (21.0 +/- 1.5 yr, 1.79 +/- 0.1 m, 82.7 +/- 14.7 kg, means +/- SD) participated in 8 wk of intense unilateral resistance training (knee extension exercise) such that one leg was trained (T) and the other acted as an untrained (UT) control. After the 8 wk of unilateral training, infusions of L-[ring-d(5)]phenylalanine, L-[ring-(13)C(6)]phenylalanine, and d(3)-alpha-ketoisocaproic acid were used to measure mixed muscle protein synthesis in the T and UT legs by the direct incorporation method [fractional synthetic rate (FSR)]. Protein synthesis was determined at rest as well as 4 h and 28 h after an acute bout of resistance exercise performed at the same intensity relative to the gain in single repetition maximum before and after training. Training increased mean muscle fiber cross-sectional area only in the T leg (type I: 16 +/- 10%; type II: 20 +/- 19%, P < 0.05). Acute resistance exercise increased muscle protein FSR in both legs at 4 h (T: 162 +/- 76%; UT: 108 +/- 62%, P < 0.01 vs. rest) with the increase in the T leg being significantly higher than in the UT leg at this time (P < 0.01). At 28 h postexercise, FSR in the T leg had returned to resting levels; however, the rate of protein synthesis in the UT leg remained elevated above resting (70 +/- 49%, P < 0.01). We conclude that resistance training attenuates the protein synthetic response to acute resistance exercise, despite higher initial increases in FSR, by shortening the duration for which protein synthesis is elevated. |
| | |
Authors:
|
Jason E Tang; Jennifer G Perco; Daniel R Moore; Sarah B Wilkinson; Stuart M Phillips |
Related Documents
:
|
11179088 - Carotid baroreflex regulation of sympathetic nerve activity during dynamic exercise in ... 19826288 - The effects of muscle mass and number of sets during resistance exercise on postexercis... 18372698 - Tibial and gastrocnemian vein response to lbnp after a 60 day bedrest with and without ... 10822318 - The effects of exercising muscle mass on post exercise hypotension. 18569968 - Standardization of cystatin c: development of primary and secondary reference preparati... 19832788 - The effects of acute exercise on attentional bias towards smoking-related stimuli durin... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-11-21 |
Journal Detail:
|
Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: 294 ISSN: 0363-6119 ISO Abbreviation: Am. J. Physiol. Regul. Integr. Comp. Physiol. Publication Date: 2008 Jan |
Date Detail:
|
Created Date: 2008-01-10 Completed Date: 2008-02-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: R172-8 Citation Subset: IM |
Affiliation:
|
Exercise Metabolism Research Group, McMaster University, Hamilton, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Amino Acids / blood Biopsy Blood Glucose / metabolism Eating / physiology* Exercise / physiology* Humans Insulin / blood Male Muscle Proteins / metabolism* Muscle Strength / physiology Muscle, Skeletal / metabolism*, pathology Time Factors Weight Lifting / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Blood Glucose; 0/Muscle Proteins; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolic rhythm abnormalities in mice lacking VIP-VPAC2 signaling.
Next Document: Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.