Document Detail

Resistance to thyroid hormone in pregnancy.
MedLine Citation:
PMID:  18669780     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Resistance to thyroid hormone manifests as high serum levels of free thyroxine and free triiodothyronine, with nonsuppressed thyroid stimulating hormone (TSH) levels. We report a case series of three patients with this condition, the changes in thyroid function tests during their pregnancies, and their obstetric outcome. CASES: Three pregnant women with asymptomatic resistance to thyroid hormone developed goiter, and the levels of TSH in one case suppressed progressively, necessitating treatment. The neonates born to all these reported cases were healthy, with normal growth scans and normal thyroid function tests at 1 week. CONCLUSION: The prenatal diagnosis of resistance to thyroid hormone is important for adequate management of both mother and fetus in pregnancy and avoiding unnecessary intervention. The only clinical manifestation of resistance to thyroid hormone may be the presence of a goiter, and treatment in asymptomatic patients solely to normalize thyroid hormone levels is not required during pregnancy. Careful evaluation of the neonate is indicated after delivery.
Simi Dhingra; Penny J D Owen; John H Lazarus; Pina Amin
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  112     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-09     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  501-3     Citation Subset:  AIM; IM    
Department of Obstetrics and Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK.
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MeSH Terms
Infant, Newborn
Pregnancy Complications / blood*
Pregnancy Outcome
Thyroid Function Tests
Thyroid Hormone Resistance Syndrome / blood*
Thyrotropin / blood
Thyroxine / blood
Reg. No./Substance:
7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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