| Resistance to thyroid hormone in pregnancy. | |
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MedLine Citation:
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PMID: 18669780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Resistance to thyroid hormone manifests as high serum levels of free thyroxine and free triiodothyronine, with nonsuppressed thyroid stimulating hormone (TSH) levels. We report a case series of three patients with this condition, the changes in thyroid function tests during their pregnancies, and their obstetric outcome. CASES: Three pregnant women with asymptomatic resistance to thyroid hormone developed goiter, and the levels of TSH in one case suppressed progressively, necessitating treatment. The neonates born to all these reported cases were healthy, with normal growth scans and normal thyroid function tests at 1 week. CONCLUSION: The prenatal diagnosis of resistance to thyroid hormone is important for adequate management of both mother and fetus in pregnancy and avoiding unnecessary intervention. The only clinical manifestation of resistance to thyroid hormone may be the presence of a goiter, and treatment in asymptomatic patients solely to normalize thyroid hormone levels is not required during pregnancy. Careful evaluation of the neonate is indicated after delivery. |
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Authors:
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Simi Dhingra; Penny J D Owen; John H Lazarus; Pina Amin |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 112 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-01 Completed Date: 2008-09-09 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 501-3 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK. sdhingra@doctors.org.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Infant, Newborn Male Pregnancy Pregnancy Complications / blood* Pregnancy Outcome Thyroid Function Tests Thyroid Hormone Resistance Syndrome / blood* Thyrotropin / blood Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
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7488-70-2/Thyroxine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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