| Resistance to multiple agent chemotherapy including cisplatin after chronic low-dose oral etoposide administration in gestational choriocarcinoma. | |
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MedLine Citation:
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PMID: 11586044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most patients with gestational trophoblastic disease in whom single-agent or even combination chemotherapy has failed can be cured with salvage chemotherapy including etoposide or platinum-based regimens. Here we report a rare case of uterine choriocarcinoma following a molar evacuation that seemed to develop during chronic low-dose oral administration of etoposide for approximately 16 months. Although the patient was expected to have a good chance of cure using combination chemotherapy, the lesion was resistant to multiple-agent chemotherapy including cisplatin. |
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Authors:
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T Okamoto; S Goto |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gynecologic and obstetric investigation Volume: 52 ISSN: 0378-7346 ISO Abbreviation: Gynecol. Obstet. Invest. Publication Date: 2001 |
Date Detail:
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Created Date: 2001-10-04 Completed Date: 2001-12-04 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 7900587 Medline TA: Gynecol Obstet Invest Country: Switzerland |
Other Details:
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Languages: eng Pagination: 139-41 Citation Subset: IM |
Copyright Information:
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Copyright 2001 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Chukyo Hospital, Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Antineoplastic Agents, Phytogenic / administration & dosage*, therapeutic use* Antineoplastic Combined Chemotherapy Protocols / administration & dosage*, therapeutic use* Choriocarcinoma / drug therapy*, secondary, surgery Cisplatin / administration & dosage*, therapeutic use* Drug Resistance, Multiple* Drug Resistance, Neoplasm* Etoposide / administration & dosage*, therapeutic use* Female Humans Hysterectomy Liver / surgery Liver Neoplasms / drug therapy, secondary, surgery Pregnancy Rectum / surgery Uterine Neoplasms / drug therapy*, pathology, surgery |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 15663-27-1/Cisplatin; 33419-42-0/Etoposide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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