Document Detail

Resistance to aspirin in patients after coronary artery bypass grafting is transient: impact on the monitoring of aspirin antiplatelet therapy.
MedLine Citation:
PMID:  16044106     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to assess the responsiveness of blood platelets to aspirin in patients following coronary artery bypass grafting (CABG) surgery. Aspirin was administered following CABG in 24 operated patients (aged 63.2 +/- 6.3 years). Platelet function was monitored on the 10th postoperative day (A) and 1 month after CABG (B) with the use of whole-blood aggregometry (WBEA) and PFA-100 closure time (PFA-100 CTCEPI). Normal platelet response to aspirin was defined by 3 criteria: the complete inhibition of WBEA induced by arachidonic acid (0.5 mmol/L), partial inhibition of collagen (1 microg/mL)-induced aggregation (WBEA < 14 Omega), and prolongation of PFA-100 CTCEPI (>150 seconds) ("good responders"). Depending on whether 0, 1, 2, or 3 of these 3 criteria were fulfilled, patients were classified as "nonresponders," "weak responders," "incomplete responders," or "good responders," respectively. On the 10th postoperative day, there were 3 good responders, 6 incomplete responders, 11 weak responders, and 4 nonresponders among 24 patients. In contrast, 1 month after CABG within the same group of 24 patients there were 18 good responders, 5 incomplete responders, and 1 weak responder. Using a new methodology to assess impaired platelet responsiveness to aspirin ex vivo, we describe here the transient nature of "aspirin resistance" following CABG. These results indicate the necessity for the prolonged monitoring of the antiplatelet effectiveness of aspirin in the postoperative period after CABG.
Jacek Golański; Stefan Chłopicki; Ryszard Golański; Peter Gresner; Alicja Iwaszkiewicz; Cezary Watala
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  27     ISSN:  0163-4356     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-26     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  United States    
Other Details:
Languages:  eng     Pagination:  484-90     Citation Subset:  IM    
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Lodz, Poland.
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MeSH Terms
Aspirin / administration & dosage,  therapeutic use*
Biological Markers / blood
Blood Platelets / drug effects,  physiology
Coronary Artery Bypass / methods*
Drug Monitoring / methods
Drug Resistance*
Middle Aged
Platelet Aggregation Inhibitors / administration & dosage,  therapeutic use*
Postoperative Period
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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