Document Detail


Resistance to antimalarial compounds: methods and applications.
MedLine Citation:
PMID:  19285915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Considerable progress has been made in antimalarial research; however, much more effort is required to develop new antimalarials which overcome plasmodial resistance to clinically available drugs and limit the emergence of resistance. In particular, research must focus on understanding the mechanisms by which Plasmodium falciparum impedes the action of these drugs. In this review, we discuss the different in vitro and in vivo models used to adequately study resistance to antimalarial compounds. For each molecule studied, the best in vitro and/or in vivo model is highlighted with a detailed discussion of its validity in relation to field data on P. falciparum resistance.
Authors:
Benoit Witkowski; Antoine Berry; Françoise Benoit-Vical
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-03-13
Journal Detail:
Title:  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy     Volume:  12     ISSN:  1532-2084     ISO Abbreviation:  Drug Resist. Updat.     Publication Date:    2009 Feb-Apr
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-05-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815369     Medline TA:  Drug Resist Updat     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  42-50     Citation Subset:  IM    
Affiliation:
CNRS, LCC (Laboratoire de Chimie de Coordination) UPR8241, 205, route de Narbonne, F-31077 Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials / chemistry,  therapeutic use*
Disease Models, Animal
Drug Design
Drug Resistance* / genetics
Genotype
Humans
Malaria / drug therapy*,  parasitology
Molecular Structure
Phenotype
Plasmodium / drug effects*,  genetics,  pathogenicity
Plasmodium falciparum / drug effects
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Antimalarials

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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