| Resistance to activated protein C in unselected patients with arterial and venous thrombosis. | |
| | |
MedLine Citation:
|
PMID: 9208999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Four hundred and ninety-three consecutive patients referred for arterial or venous thrombosis were screened for congenital and acquired abnormalities of blood coagulation predisposing to thrombosis, and were compared to 341 age- and sex-matched controls. The aim of the study was to determine the prevalence and clinical characteristics of resistance to activated protein C (APC), a defect shown to have different prevalences in different ethnic groups and to be associated with an increased risk of thrombosis. Seventy-three (15%) patients had both APC resistance and the 1691 G to A factor V gene mutation, compared to 6/341 (2%) controls. Seven patients had antithrombin deficiency (1.4%), 11 had protein C deficiency (2.2%), and 4 had protein S deficiency (0.8%). The relative risk of thrombosis in APC-resistant patients was 9.4. Resistance to APC was associated mainly with venous thrombosis, the most frequent being deep-vein thrombosis of the lower limbs. Fifty-eight percent of APC-resistant patients had an associated risk factor at the first thrombotic event: pregnancy and oral contraceptive intake were associated with the first thrombotic episode in 35% and 30% of women, respectively. APC resistance is the most frequent defect of blood coagulation in the general population and in the unselected thrombotic population studied by us. |
| | |
Authors:
|
E M Faioni; C Razzari; I Martinelli; D Panzeri; F Franchi; P M Mannucci |
Related Documents
:
|
15249589 - Phase i study of an immunomodulatory thalidomide analog, cc-4047, in relapsed or refrac... 8417489 - Four-compartment fasciotomy and venous calf-pump function: long-term results. 11796959 - Effect of tissue injury on d-dimer levels: a prospective study in trauma patients. 15154879 - Tryptophan-immobilized column-based immunoadsorption as the choice method for plasmaphe... 7473949 - Asymptomatic deep venous thrombosis in the trauma patient: is an aggressive screening p... 1307879 - Superior vena cava syndrome: etiology, diagnosis, and treatment. 21666989 - Investigation of the association between metabolic syndrome and disease activity in rhe... 20346239 - Visfatin is not associated with inflammation or metabolic syndrome in patients with sev... 23031329 - Increased adamts13 activity in patients with venous thromboembolism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of hematology Volume: 55 ISSN: 0361-8609 ISO Abbreviation: Am. J. Hematol. Publication Date: 1997 Jun |
Date Detail:
|
Created Date: 1997-07-24 Completed Date: 1997-07-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7610369 Medline TA: Am J Hematol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
|
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, I.R.C.C.S. Maggiore Hospital and Institute of Internal Medicine, University of Milan, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Coagulation Disorders / physiopathology* Contraceptives, Oral / adverse effects Enzyme Activation Factor V / genetics* Female Humans Male Middle Aged Point Mutation Pregnancy Pregnancy Complications, Hematologic Protein C / metabolism* Protein C Deficiency Protein S Deficiency / complications Risk Factors Thrombosis / physiopathology* |
| Chemical | |
Reg. No./Substance:
|
0/Contraceptives, Oral; 0/Protein C; 9001-24-5/Factor V |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treatment of plasma refractory thrombotic thrombocytopenic purpura with protein A immunoabsorption.
Next Document: Prenatal diagnosis of thalassemia in the Chinese.