Document Detail

Resistance to activated protein C in unselected patients with arterial and venous thrombosis.
MedLine Citation:
PMID:  9208999     Owner:  NLM     Status:  MEDLINE    
Four hundred and ninety-three consecutive patients referred for arterial or venous thrombosis were screened for congenital and acquired abnormalities of blood coagulation predisposing to thrombosis, and were compared to 341 age- and sex-matched controls. The aim of the study was to determine the prevalence and clinical characteristics of resistance to activated protein C (APC), a defect shown to have different prevalences in different ethnic groups and to be associated with an increased risk of thrombosis. Seventy-three (15%) patients had both APC resistance and the 1691 G to A factor V gene mutation, compared to 6/341 (2%) controls. Seven patients had antithrombin deficiency (1.4%), 11 had protein C deficiency (2.2%), and 4 had protein S deficiency (0.8%). The relative risk of thrombosis in APC-resistant patients was 9.4. Resistance to APC was associated mainly with venous thrombosis, the most frequent being deep-vein thrombosis of the lower limbs. Fifty-eight percent of APC-resistant patients had an associated risk factor at the first thrombotic event: pregnancy and oral contraceptive intake were associated with the first thrombotic episode in 35% and 30% of women, respectively. APC resistance is the most frequent defect of blood coagulation in the general population and in the unselected thrombotic population studied by us.
E M Faioni; C Razzari; I Martinelli; D Panzeri; F Franchi; P M Mannucci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  55     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-24     Completed Date:  1997-07-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  59-64     Citation Subset:  IM    
Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, I.R.C.C.S. Maggiore Hospital and Institute of Internal Medicine, University of Milan, Italy.
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MeSH Terms
Blood Coagulation Disorders / physiopathology*
Contraceptives, Oral / adverse effects
Enzyme Activation
Factor V / genetics*
Middle Aged
Point Mutation
Pregnancy Complications, Hematologic
Protein C / metabolism*
Protein C Deficiency
Protein S Deficiency / complications
Risk Factors
Thrombosis / physiopathology*
Reg. No./Substance:
0/Contraceptives, Oral; 0/Protein C; 9001-24-5/Factor V

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