Document Detail


Resistance to activated protein C as an underlying cause of recurrent venous thrombosis during relapsing nephrotic syndrome.
MedLine Citation:
PMID:  7608792     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 16-year-old patient with relapsing nephrotic syndrome had three episodes of deep vein thrombosis after the age of 15 years. An autosomal inherited genetic abnormality of clotting factor V, resistance to activated protein C, was found. The clinical course showed that this resistance and the nephrotic syndrome potentiated each other as risk factors for deep vein thrombosis, and long-term anticoagulation was indicated.
Authors:
J Petäjä; H Jalanko; C Holmberg; S Kinnunen; M Syrjälä
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  127     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-08-11     Completed Date:  1995-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  103-5     Citation Subset:  AIM; IM    
Affiliation:
Children's Hospital and Laboratory Department, Helsinki University Central Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Antithrombins / therapeutic use
Humans
Long-Term Care
Male
Nephrotic Syndrome / complications*
Protein C / physiology*
Recurrence
Thrombophlebitis / blood*,  complications*,  drug therapy
Warfarin / therapeutic use
Chemical
Reg. No./Substance:
0/Antithrombins; 0/Protein C; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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