Document Detail

Resistance to Marek's disease herpesvirus-induced lymphoma is multiphasic and dependent on host genotype.
MedLine Citation:
PMID:  11280369     Owner:  NLM     Status:  MEDLINE    
Genotype-dependent differences in Marek's disease (MD) susceptibility were identified using 14-day-old line N and 6(1) (resistant) and 151 and 7(2) (susceptible) inbred chickens infected with HPRS-16 MD virus (MDV). All line 72 chickens developed progressive MD. Line 15I had fluctuating MD-specific clinical signs and individuals recovered. A novel histologic scoring system enabled indices to be calculated for lymphocyte infiltration into nonlymphoid organs. All genotypes had increased mean lesion scores (MLSs) and mean total lesion scores after MDV infection. These differed quantitatively and qualitatively between the genotypes. Lines 6(1) and 7(2) had a similar MLS distribution in the cytolytic phase, although scores were greater in line 7(2). At the time lymphomas were visible in line 7(2), histologic lesions in line 6(1) were regressing. AV37+ cells were present in similar numbers in all genotypes in the cytolytic phase, suggesting that neoplastically transformed cells were present in all genotypes regardless of MD susceptibility. After the cytolytic phase, AV37+ cell numbers increased in lines 7(2) and 15I but decreased in lines 6(1) and N. In the cytolytic and latent phases, in all genotypes, most infiltrating cells were CD4+. After this time, line 7(2) and 15I lesions increased in size and most cells were CD4+; line 6(1) and N lesions decreased in size and most cells were CD8+. In all genotypes, AV37 immunostaining was weak in lesions with many CD8+ cells, suggesting that AV37 antigen expression or AV37+ cells were controlled by CD8+ cells. The rank order, determined by clinical signs and pathology, for MD susceptibility (highest to lowest) was 7(2) > 15I > 6(1) > N.
S C Burgess; B H Basaran; T F Davison
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  38     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-06-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-42     Citation Subset:  IM    
Division of Immunopathology, Institute for Animal Health, Compton, Newbury, Berks, UK.
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MeSH Terms
Antibodies, Monoclonal / immunology
Cell Transformation, Viral / genetics,  immunology
Chickens / genetics*
DNA, Viral / chemistry
Genetic Predisposition to Disease
Gonads / pathology
Herpesvirus 2, Gallid / pathogenicity*
Immunohistochemistry / veterinary
Liver / pathology
Lymphoma / genetics*,  immunology,  pathology,  virology*
Marek Disease / complications,  genetics*,  pathology
Polymerase Chain Reaction / veterinary
Poultry Diseases / genetics*,  pathology,  virology
Proventriculus / pathology
Sciatic Neuropathy / pathology,  veterinary
Skin / pathology
Specific Pathogen-Free Organisms
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/DNA, Viral

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