Document Detail


Resistance to Intranasal Infection with Balamuthia mandrillaris Amoebae is T Cell-dependent.
MedLine Citation:
PMID:  25363468     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
T and B cell-deficient BALB/c SCID mice become severely ill and die of amoebic encephalitis after intranasal infection with Balamuthia mandrillaris, while adult immunocompetent BALB/c wild-type (WT) mice are resistant. To further investigate the role of lymphocytes in protection from Balamuthia amoebic encephalitis (BAE), SCID mice were reconstituted with and WT mice selectively depleted of lymphocytes before infection. Reconstitution of SCID mice with whole spleen cells from WT mice rendered the recipients as resistant to BAE as WT mice. SCID mice that had received spleen cells depleted of CD4(+) T cells remained susceptible. When adult WT mice were depleted of both CD4(+) and CD8(+) T cells or of CD4(+) T cells alone, these mice also became susceptible to BAE. Depletion of CD8(+) T cells alone increased susceptibility only marginally. All morbidity and mortality data were underpinned by histological analysis of the brain. This article is protected by copyright. All rights reserved.
Authors:
Albrecht F Kiderlen; Elke Radam; Ulrike Laube; A J Martínez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-2
Journal Detail:
Title:  The Journal of eukaryotic microbiology     Volume:  -     ISSN:  1550-7408     ISO Abbreviation:  J. Eukaryot. Microbiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-3     Completed Date:  -     Revised Date:  2014-11-5    
Medline Journal Info:
Nlm Unique ID:  9306405     Medline TA:  J Eukaryot Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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