| Resistance of the rabbit to dietary pyrrolizidine (Senecio) alkaloid. | |
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MedLine Citation:
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PMID: 847303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rabbits were fed Senecio jacobaea for 263 days. Total intake of the plant averaged 112.5% of initial body weight. No gross lesions, or changes in serum protein and albumin occurred. Microscopic changes in liver tissue were seen. Two rabbits injected with 150 mg Senecio pyrrolizidine alkaloid/kg body weight died in less than 24 hours. The resistance of the rabbit to chronic Senecio intoxication, but not to injected alkaloid, suggests that alkaloid absorption may be low in this species. |
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Authors:
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M L Pierson; P R Cheeke; E O Dickinson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 16 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1977 Mar |
Date Detail:
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Created Date: 1977-05-20 Completed Date: 1977-05-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 561-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Proteins / metabolism Diet Drug Resistance Female Injections, Intraperitoneal Liver / anatomy & histology, drug effects Male Plants, Toxic* Pyrrolizidine Alkaloids / administration & dosage, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Pyrrolizidine Alkaloids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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