| Resistance of neonatal primary astrocytes against Fas-induced apoptosis depends on silencing of caspase 8. | |
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MedLine Citation:
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PMID: 20510339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present report, we have found that primary fetal astrocytes express caspase 8 and undergo apoptosis in response to Fas ligation. In contrast, neonatal astrocytes do not express detectable levels of the enzyme and are resistant to Fas killing. Fas-induced apoptosis can be restored in these cells by up-regulation of caspase 8 expression by means of transient transfection with a caspase 8-encoding plasmid. Furthermore, treatment of primary astrocytes with the demethylating agent 5-Aza-dC restores caspase 8 expression and increases the sensibility of neonatal astrocytes to the cytotoxic effect of Fas activation. Altogether, our findings indicate that silencing of caspase 8 gene is a key factor controlling the outcome of neonatal astrocytes upon Fas engagement. |
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Authors:
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Olga Barca; Carmen Carneiro; José A Costoya; Rosa M Señarís; Víctor M Arce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-25 |
Journal Detail:
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Title: Neuroscience letters Volume: 479 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 206-10 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Departamento de Fisioloxía, Facultade de Medicina, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Apoptosis* Astrocytes / cytology* Caspase 8 / biosynthesis, genetics* Cerebral Cortex / cytology Gene Silencing Rats Rats, Sprague-Dawley Up-Regulation |
| Chemical | |
Reg. No./Substance:
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EC 3.4.22.-/Caspase 8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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