Document Detail


Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]
MedLine Citation:
PMID:  1816768     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel non-immunosuppressive cyclosporin [corrected], PSC-833, has been tested for its ability to circumvent resistance to doxorubicin, vincristine and colchicine in human and murine multidrug resistant (MDR) cell lines. This compound is shown to be a highly potent resistance modifier, being 7-10-fold more potent than the parent compound, cyclosporin A, whilst approximately equal to cyclosporin A in the growth inhibitory effects of compound alone. Reversal of the P-glycoprotein-associated MDR drug accumulation defect is a major component of resistance reversal for PSC-833, as it is for cyclosporin A.
Authors:
P R Twentyman; N M Bleehen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  27     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1639-42     Citation Subset:  IM    
Affiliation:
MRC Clinical Oncology, Radiotherapeutics Unit, Cambridge, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Survival / drug effects
Colchicine / pharmacology
Cyclosporine / pharmacology*
Cyclosporins / pharmacology*
Doxorubicin / pharmacology
Drug Resistance
Humans
Mice
Tumor Cells, Cultured / drug effects
Vincristine / pharmacology
Chemical
Reg. No./Substance:
0/Cyclosporins; 121584-18-7/valspodar; 23214-92-8/Doxorubicin; 57-22-7/Vincristine; 59865-13-3/Cyclosporine; 64-86-8/Colchicine
Comments/Corrections
Erratum In:
Eur J Cancer 1992;28(2-3):616

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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