Document Detail

Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin [corrected]
MedLine Citation:
PMID:  1816768     Owner:  NLM     Status:  MEDLINE    
A novel non-immunosuppressive cyclosporin [corrected], PSC-833, has been tested for its ability to circumvent resistance to doxorubicin, vincristine and colchicine in human and murine multidrug resistant (MDR) cell lines. This compound is shown to be a highly potent resistance modifier, being 7-10-fold more potent than the parent compound, cyclosporin A, whilst approximately equal to cyclosporin A in the growth inhibitory effects of compound alone. Reversal of the P-glycoprotein-associated MDR drug accumulation defect is a major component of resistance reversal for PSC-833, as it is for cyclosporin A.
P R Twentyman; N M Bleehen
Related Documents :
24934538 - Comparison of detection methods for extended-spectrum beta-lactamases in escherichia co...
24338078 - Selection of indigenous isolates of entomopathogenic soil fungus metarhizium anisopliae...
17362328 - Leaf rust (puccinia triticina) resistance in wheat (triticum aestivum) cultivars grown ...
16659278 - Characterization of carrot and tobacco cell cultures resistant to p-fluorophenylalanine.
18846398 - Genome shuffling to improve thermotolerance, ethanol tolerance and ethanol productivity...
19357158 - Mutational analysis of quinolone resistance in the plasmid-encoded pentapeptide repeat ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  27     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1639-42     Citation Subset:  IM    
MRC Clinical Oncology, Radiotherapeutics Unit, Cambridge, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Survival / drug effects
Colchicine / pharmacology
Cyclosporine / pharmacology*
Cyclosporins / pharmacology*
Doxorubicin / pharmacology
Drug Resistance
Tumor Cells, Cultured / drug effects
Vincristine / pharmacology
Reg. No./Substance:
0/Cyclosporins; 121584-18-7/valspodar; 23214-92-8/Doxorubicin; 57-22-7/Vincristine; 59865-13-3/Cyclosporine; 64-86-8/Colchicine
Erratum In:
Eur J Cancer 1992;28(2-3):616

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of adrenaline on blood perfusion and vascular conductance of the whole pancreas and the is...
Next Document:  How one achieves the practice of medicine in Puerto Rico--1990