Document Detail


Resistance in pediatric patients experiencing virologic failure with first-line and second-line antiretroviral therapy.
MedLine Citation:
PMID:  23303240     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined HIV-1 resistance in children failing first-line and second-line antiretroviral therapy in South Africa, all with clade C virus. Those exposed to full-dose ritonavir had multiple protease resistance mutations. Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options.
Authors:
Catherine Orrell; Julie Levison; Andrea Ciaranello; Linda-Gail Bekker; Daniel R Kuritzkes; Kenneth A Freedberg; Robin Wood
Publication Detail:
Type:  Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  32     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-07-11     Completed Date:  2014-02-06     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  644-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Anti-Retroviral Agents / pharmacology,  therapeutic use*
Child
Child, Preschool
Cohort Studies
Drug Resistance, Viral*
Female
Genotype
HIV Infections / drug therapy*,  virology*
HIV-1 / drug effects*,  genetics,  isolation & purification
Humans
Infant
Male
Microbial Sensitivity Tests / methods
RNA, Viral / genetics
Retrospective Studies
Ritonavir / pharmacology,  therapeutic use
South Africa
Treatment Failure
Grant Support
ID/Acronym/Agency:
K01 AI078754/AI/NIAID NIH HHS; K01 AI078754/AI/NIAID NIH HHS; R01 AI058736/AI/NIAID NIH HHS; R01 AI085736/AI/NIAID NIH HHS; UM1 AI068636/AI/NIAID NIH HHS; UM1 AI068636/AI/NIAID NIH HHS; //PEPFAR
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/RNA, Viral; O3J8G9O825/Ritonavir
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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