Document Detail

Resistance of gram-negative bacilli as related to hospital use of antimicrobial agents.
MedLine Citation:
PMID:  6638994     Owner:  NLM     Status:  MEDLINE    
The development of resistance of gram-negative bacilli, which are common nosocomial pathogens, is an increasing problem. It is generally accepted that this resistance may directly reflect the frequency of use of various antimicrobial agents. Because our institution experienced in 1976 a dramatic change in the pattern of antimicrobial use, primarily a marked decrease in prescribing cephalosporins, we attempted to evaluate retrospectively the effects of this change upon the resistance of gram-negative bacilli that are common nosocomial pathogens. Susceptibilities of Klebsiella and Providencia spp., Pseudomonas aeruginosa, and Serratia marcescens were determined for the years 1975 to 1979. Not unexpectedly, we observed a substantial decrease in cephalosporin resistance. An unexpected finding was a decrease in aminoglycoside resistance, despite increased use of these agents. The possibility that decreased cephalosporin use may lead to decreased aminoglycoside resistance is an intriguing and provocative thesis which can only be speculative at this time but which would seem worthy of additional formal investigation.
M Y Ma; E J Goldstein; M H Friedman; M S Anderson; M E Mulligan
Related Documents :
12674864 - Pneumocystis pneumonia.
17847174 - Emerging issues in the management of infections caused by multidrug-resistant gram-nega...
17900874 - Introduction: historical perspective and development of amoxicillin/clavulanate.
17896904 - Prevalence, consequences, and solutions.
17499454 - Phytochemical and antiprotozoal activity of ocotea lancifolia.
19794054 - First neisseria gonorrhoeae genotyping analysis in france: identification of a strain c...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  24     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-52     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aminoglycosides / pharmacology
Anti-Bacterial Agents / pharmacology*
Cephalosporins / pharmacology
Drug Resistance, Microbial*
Gram-Negative Bacteria / drug effects*
Reg. No./Substance:
0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Cephalosporins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pre...
Next Document:  Developmental pharmacokinetics of moxalactam.