Document Detail


Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >/=76 yr old.
MedLine Citation:
PMID:  10409135     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Muscle atrophy (sarcopenia) in the elderly is associated with a reduced rate of muscle protein synthesis. The purpose of this study was to determine if weight-lifting exercise increases the rate of muscle protein synthesis in physically frail 76- to 92-yr-old women and men. Eight women and 4 men with mild to moderate physical frailty were enrolled in a 3-mo physical therapy program that was followed by 3 mo of supervised weight-lifting exercise. Supervised weight-lifting exercise was performed 3 days/wk at 65-100% of initial 1-repetition maximum on five upper and three lower body exercises. Compared with before resistance training, the in vivo incorporation rate of [(13)C]leucine into vastus lateralis muscle protein was increased after resistance training in women and men (P < 0.01), although it was unchanged in five 82 +/- 2-yr-old control subjects studied two times in 3 mo. Maximum voluntary knee extensor muscle torque production increased in the supervised resistance exercise group. These findings suggest that muscle contractile protein synthetic pathways in physically frail 76- to 92-yr-old women and men respond and adapt to the increased contractile activity associated with progressive resistance exercise training.
Authors:
K E Yarasheski; J Pak-Loduca; D L Hasten; K A Obert; M B Brown; D R Sinacore
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-18     Completed Date:  1999-08-18     Revised Date:  2012-06-11    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E118-25     Citation Subset:  IM; S    
Affiliation:
Claude D. Pepper Older American's Independence Center, Divisions of Geriatrics and Gerontology and Metabolism, Endocrinology, and Diabetes, Washington University Medical Center, St. Louis, Missouri 63110, USA. key@imgate.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Body Composition / physiology
Creatinine / urine
Female
Frail Elderly*
Humans
Leg
Male
Methylhistidines / urine
Muscle Proteins / biosynthesis*
Muscle, Skeletal / anatomy & histology,  metabolism,  physiology
Organ Size / physiology
Physical Education and Training*
Sex Characteristics
Weight Lifting*
Grant Support
ID/Acronym/Agency:
AG-13629/AG/NIA NIH HHS; DK-49393/DK/NIDDK NIH HHS; P41 RR000954/RR/NCRR NIH HHS; P60 AG013629/AG/NIA NIH HHS; RR-00954/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Methylhistidines; 0/Muscle Proteins; 368-16-1/3-methylhistidine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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