| Resistance exercise training increases mixed muscle protein synthesis rate in frail women and men >/=76 yr old. | |
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MedLine Citation:
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PMID: 10409135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Muscle atrophy (sarcopenia) in the elderly is associated with a reduced rate of muscle protein synthesis. The purpose of this study was to determine if weight-lifting exercise increases the rate of muscle protein synthesis in physically frail 76- to 92-yr-old women and men. Eight women and 4 men with mild to moderate physical frailty were enrolled in a 3-mo physical therapy program that was followed by 3 mo of supervised weight-lifting exercise. Supervised weight-lifting exercise was performed 3 days/wk at 65-100% of initial 1-repetition maximum on five upper and three lower body exercises. Compared with before resistance training, the in vivo incorporation rate of [(13)C]leucine into vastus lateralis muscle protein was increased after resistance training in women and men (P < 0.01), although it was unchanged in five 82 +/- 2-yr-old control subjects studied two times in 3 mo. Maximum voluntary knee extensor muscle torque production increased in the supervised resistance exercise group. These findings suggest that muscle contractile protein synthetic pathways in physically frail 76- to 92-yr-old women and men respond and adapt to the increased contractile activity associated with progressive resistance exercise training. |
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Authors:
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K E Yarasheski; J Pak-Loduca; D L Hasten; K A Obert; M B Brown; D R Sinacore |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 277 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-18 Completed Date: 1999-08-18 Revised Date: 2012-06-11 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E118-25 Citation Subset: IM; S |
Affiliation:
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Claude D. Pepper Older American's Independence Center, Divisions of Geriatrics and Gerontology and Metabolism, Endocrinology, and Diabetes, Washington University Medical Center, St. Louis, Missouri 63110, USA. key@imgate.wustl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Body Composition / physiology Creatinine / urine Female Frail Elderly* Humans Leg Male Methylhistidines / urine Muscle Proteins / biosynthesis* Muscle, Skeletal / anatomy & histology, metabolism, physiology Organ Size / physiology Physical Education and Training* Sex Characteristics Weight Lifting* |
| Grant Support | |
ID/Acronym/Agency:
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AG-13629/AG/NIA NIH HHS; DK-49393/DK/NIDDK NIH HHS; P41 RR000954/RR/NCRR NIH HHS; P60 AG013629/AG/NIA NIH HHS; RR-00954/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Methylhistidines; 0/Muscle Proteins; 368-16-1/3-methylhistidine; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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