| Resistance of central nervous system interleukin-6 to glucocorticoid inhibition in monkeys. | |
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MedLine Citation:
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PMID: 9688700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of both exogenous and endogenous glucocorticoids (GCs) to inhibit proinflammatory cytokine production was investigated in vivo. Specifically, we investigated the effects of elevated GC levels on interleukin (IL)-1-induced release of IL-6 into both blood and cerebrospinal fluid (CSF). Three experiments were conducted in rhesus macaques to elevate corticoid levels for at least 4 h before administration of IL-1beta. The first study used dexamethasone pretreatment, the second utilized ACTH to stimulate endogenous cortisol release, while the third relied on a psychological challenge to stimulate the hypothalamic-pituitary-adrenal axis. Contrary to our a priori predictions, none of these treatments attenuated the IL-1-induced release of IL-6 into CSF. Additionally, the pattern in the blood response was similar, such that the IL-6 response was not blocked, although there was a trend toward a reduction of this response. These data indicated that the IL-1-induced IL-6 response is for the most part resistant to corticosteroid influence, such that even when a partial inhibition was sometimes evident in blood, cytokine release in the central nervous system was not affected. |
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Authors:
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T M Reyes; C L Coe |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 275 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-16 Completed Date: 1998-09-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R612-8 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of Wisconsin, Madison, Wisconsin 53706, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenocorticotropic Hormone
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pharmacology*,
physiology Analysis of Variance Animals Dexamethasone / pharmacology* Female Humans Hydrocortisone / physiology, secretion Interleukin-1 / pharmacology* Interleukin-6 / blood, cerebrospinal fluid* Macaca mulatta Male Recombinant Proteins / pharmacology Stress, Psychological / blood, cerebrospinal fluid*, immunology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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MH-41659/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-6; 0/Recombinant Proteins; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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