| Resistance of ascending vasa recta to transport of water. | |
| | |
MedLine Citation:
|
PMID: 1705755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A study was undertaken to determine the effect of increasing capillary pressure on volume flux in ascending vasa recta (AVR). In one experiment (group I), AVR were blocked by a single injection of paraffin wax and subjected to free-flow microperfusion at 10 nl/min. Collected fluid was obtained from the perfused vessels by micropuncture. In a second experiment (group II), AVR segments were isolated between two paraffin blocks and perfused at 10 nl/min. In group II, the collection pipette was pressurized to 0, 10, or 20 mmHg. Transmembrane volume flux was determined by measuring the change in concentration of fluorescein isothiocyanate-labeled dextran (2 x 10(6) mol wt) from perfusate to collected fluid. In group I, measurements revealed a capillary pressure of 10.3 +/- 0.5 (SE) mmHg and volume flux of 4.3 +/- 1.0 nl.mm-1.min-1. In group II, volume flux was 1.8 +/- 1.3, 5.9 +/- 1.0, and 11.2 +/- 1.1 nl.mm-1.min-1 at collection pressures of 0, 10, or 20 mmHg, respectively. Based on these data and an AVR diameter of 20 microns, AVR hydraulic conductivity is between 12.5 x 10(-6) and 18.7 x 10(-6) cm.s-1.mmHg-1. The papillary AVR have a high hydraulic conductivity. This is consistent with their role as the sole conduit for removal of water from the papillary interstitium. |
| | |
Authors:
|
T L Pallone |
Related Documents
:
|
2810115 - Influence of protein kinase c activators on vascular tone and adrenergic neuroeffector ... 4043155 - Prevention of edema formation in the perfused lung preparation by oxygen radical scaven... 9267635 - Measurement of vasoactivity in the guinea-pig choroid. 14563675 - Gender differences in small intestinal endothelial function: inhibitory role of androgens. 8758045 - Predictors of outcome in cryptococcus neoformans var. gattii meningitis. 18479925 - Jugular phlebectasia: a manometric study in an unanesthetized patient. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The American journal of physiology Volume: 260 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1991-04-11 Completed Date: 1991-04-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: F303-10 Citation Subset: IM |
Affiliation:
|
Division of Nephrology, M. S. Hershey Medical Center of Pennsylvania State University, Hershey 17033. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biological Transport Body Water / metabolism* Capillaries / metabolism Dextrans / diagnostic use Female Fluorescein-5-isothiocyanate* / analogs & derivatives* Fluoresceins / diagnostic use Kidney Medulla / blood supply* Microcirculation Rats Rats, Inbred Strains Vascular Resistance* |
| Grant Support | |
ID/Acronym/Agency:
|
DK-424495-01/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Fluoresceins; 0/fluorescein isothiocyanate dextran; 3326-32-7/Fluorescein-5-isothiocyanate; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Basal cell-specific and hyperproliferation-related keratins in human breast cancer.
Next Document: Carbonic anhydrase in turtle bladder mitochondrial-rich luminal and subluminal cells.