Document Detail

Resistance Training Reduces Subclinical Inflammation in Obese, Postmenopausal Women.
MedLine Citation:
PMID:  22874536     Owner:  NLM     Status:  Publisher    
PURPOSE: Aerobic exercise is frequently prescribed to reduce inflammatory-related disease (CVD, diabetes) risk. Resistance training (RT), however, may be key to maximizing antiinflammatory benefits of consistent exercise. We examined the influence of RT on inflammatory biomarkers in obese, postmenopausal women. METHODS: Twenty-three women (65.6±2.6 yr; BMI: 33 kg[BULLET OPERATOR]m) underwent twelve weeks RT (3 sets, 10 exercises, 3X/week, 8-12 RM, EX, N=11) or social interaction intervention (SI, stretching, knitting, health lectures, 2X/week, CON, N=12). Both before (BT) and after (AT) RT or SI, blood was collected before (PR), immediately (PO), 2h (2H) and 24h (24H) after a single resistance exercise bout (RE) in EX, and at the same time points in non-exercise, resting CON. For all time points blood was analyzed for IL-6, leptin, and LPS-stimulated TNF-α (LPS-TNF) and IL-10 (LPS-IL10). PR samples were also examined for CRP, TNF-α, and adiponectin, and mRNA expression of TLR4 and MC1R. Subcutaneous adipose tissue (SCAT) was extracted BT and AT and analyzed for mRNA expression of MCP-1, leptin, CD68, and TLR4. RESULTS: RT improved strength (44%) and reduced circulating CRP (-33%), leptin (-18%) and TNF-α (-29%) with no change in body composition. IL-6 decreased after SI in CON (-17%). LPS-TNF increased after SI or RT (CON +26%, EX +67%, respectively) while LPS- IL10 decreased in CON (-28%), but increased in EX (+20%). RT did not influence inflammatory biomarker gene expression in whole blood or SCAT. A single RE bout augmented LPS-TNF and LPS-IL10 at 24H in EX, particularly AT. CONCLUSION: RT reduced markers of subclinical inflammation in circulation in obese, postmenopausal women in the absence of changes in body composition. Chronic RT alsoenhanced response to endotoxin challenge both at rest (PR) and 24 h after an acute RE bout (24H).
Melody D Phillips; Robert M Patrizi; Dennis J Cheek; Joshua S Wooten; James J Barbee; Joel B Mitchell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Texas Christian University, Exercise Physiology Laboratory, Fort Worth, TX76129 2Texas Christian University, Nursing Research Laboratory, Fort Worth, TX 76129 3Institute for Women's Health, Texas Woman's University, Denton, TX 76204 4JPS Health Network, Division of Primary Care Sports Medicine, Arlington, TX 76018.
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