Document Detail


Resistance of Plasmodium falciparum malaria to amodiaquine, chloroquine and quinine in the Madang Province of Papua New Guinea, 1990-1993.
MedLine Citation:
PMID:  9522846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vivo response of Plasmodium falciparum parasites to amodiaquine or chloroquine was assessed in children with symptomatic malaria attending different health facilities in the Madang area. Among the 27 subjects who were completely followed up, 4 (15%) were infected with parasites fully susceptible and 23 (85%) with parasites exhibiting some degree of resistance. Out of the latter group, 52% were of RI level, 26% RII and 22% RIII. 14 subjects out of 42 (33%) failed to clear their parasitaemia by day 7 and 92 out of 134 (69%) had persistent or recrudescent parasitaemia at day 21. The level of in vivo resistance was similar for amodiaquine and chloroquine. 86% of the isolates tested in vitro showed resistance to amodiaquine, 86% to chloroquine and 7% to quinine. In ten years the prevalence of resistant isolates in vivo has increased from 47% to 85%. Of more concern is the shift from RI level of resistance to RII and RIII: the proportion of resistant strains that were RI dropped from 90% to 52% over the ten-year period. To determine if the standard antimalarial regimens are still appropriate, there is a need not only to assess the level of parasite resistance but also the prevalence of treatment failure in different parts of Papua New Guinea.
The in vivo response of Plasmodium falciparum parasites to amodiaquine and chloroquine was assessed in children 1-9 years of age with symptomatic malaria recruited from health centers in Papua New Guinea's Madang area. Among the 27 children who were completely followed up, 4 (15%) were infected with fully susceptible parasites; in the remaining 23 cases (85%), there was some degree of resistance. 52% of parasites in the latter group were RI level, 26% RII, and 22% RIII. There was no correlation between level of resistance and age. 14 out of 42 children (33%) failed to clear their parasitemia by day 7 and 92 out of 134 (69%) had persistent or recrudescent parasitemia at day 21. Both amodiaquine and chloroquine had similar levels of in vivo resistance. 86% of isolates tested in vitro showed resistance to amodiaquine, 86% to chloroquine, and 7% to quinine. In 10 years, the prevalence of resistant isolates in vivo has increased from 47% to 85%. Of particular concern is the finding that the proportion of resistant strains that were RI dropped from 90% to 52% over this decade. The increase of resistance is attributed to indiscriminate use of 4-aminoquinolines in all cases of fever. Needed, to assess whether standard antimalarial regimens are still appropriate, is a review of treatment failure in different parts of Papua New Guinea.
Authors:
F al-Yaman; B Genton; D Mokela; A Narara; A Raiko; M P Alpers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Papua and New Guinea medical journal     Volume:  39     ISSN:  0031-1480     ISO Abbreviation:  P N G Med J     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376417     Medline TA:  P N G Med J     Country:  PAPUA NEW GUINEA    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  IM; J    
Affiliation:
Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Amodiaquine / therapeutic use*
Animals
Antimalarials / therapeutic use*
Case-Control Studies
Child
Child, Preschool
Chloroquine / therapeutic use*
Drug Resistance
Female
Follow-Up Studies
Humans
Infant
Malaria, Cerebral / drug therapy
Malaria, Falciparum / drug therapy*
Male
Papua New Guinea
Parasitemia / drug therapy
Plasmodium falciparum / drug effects*
Prevalence
Quinine / therapeutic use*
Recurrence
Treatment Failure
Chemical
Reg. No./Substance:
0/Antimalarials; 130-95-0/Quinine; 54-05-7/Chloroquine; 86-42-0/Amodiaquine

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