| Resistance exercise training influences skeletal muscle immune activation: a microarray analysis. | |
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MedLine Citation:
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PMID: 22052873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The primary aim of this investigation was to evaluate the effect of training on the immune activation in skeletal muscle in response to an acute bout of resistance exercise (RE). Seven young healthy men and women underwent a 12-wk supervised progressive unilateral arm RE training program. One week after the last training session, subjects performed an acute bout of bilateral RE in which the trained and the untrained arm exercised at the same relative intensity. Muscle biopsies were obtained 4 h postexercise from the biceps brachii of both arms and assessed for global transcriptom using Affymetrix U133 plus 2.0 microarrays. Significantly regulated biological processes and gene groups were analyzed using a logistic regression-based method following differential (trained vs. untrained) gene expression testing via an intensity-based Bayesian moderated t-test. The results from the present study suggest that training blunts the transcriptional upregulation of immune activation by minimizing expression of genes involved in monocyte recruitment and enhancing gene expression involved in macrophage anti-inflammatory polarization. Additionally, our data suggest that training blunts the transcriptional upregulation of the stress response and the downregulation of glucose metabolism, mitochondrial structure, and oxidative phosphorylation, and it enhances the transcriptional upregulation of the extracellular matrix and cytoskeleton development and organization and the downregulation of gene transcription and muscle contraction. This study provides novel insight into the molecular processes involved in the adaptive response of skeletal muscle following RE training and the cellular and molecular events implicating the protective role of training on muscle stress and damage inflicted by acute mechanical loading. |
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Authors:
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Paul M Gordon; Dongmei Liu; Maureen A Sartor; Heidi B IglayReger; Emidio E Pistilli; Laurie Gutmann; Gustavo A Nader; Eric P Hoffman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-03 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 112 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-03 Completed Date: 2012-08-23 Revised Date: 2013-04-08 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 443-53 Citation Subset: IM |
Affiliation:
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University of Michigan, Ann Arbor, Michigan 48108, USA. gordonp@med.umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Arm / physiology Bayes Theorem Cytoskeleton / genetics, immunology, metabolism Down-Regulation / genetics, immunology Extracellular Matrix / genetics, immunology, metabolism Female Gene Expression Glucose / genetics, metabolism Humans Macrophages / immunology, metabolism Male Microarray Analysis / methods Mitochondria / genetics, immunology, metabolism Muscle Contraction / genetics, immunology Muscle, Skeletal / immunology*, metabolism Oxidative Phosphorylation Resistance Training* Stress, Physiological / genetics, immunology Transcriptome / genetics, immunology* Up-Regulation Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01-NS40606-01A1/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-99-7/Glucose |
| Comments/Corrections | |
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