Document Detail


Resistance exercise did not alter intramuscular adipose tissue but reduced retinol-binding protein-4 concentration in individuals with type 2 diabetes mellitus.
MedLine Citation:
PMID:  20819415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid accumulation in muscle is associated with diminished insulin sensitivity. It was hypothesized that resistance exercise decreases muscular adipose tissue and reduces the level of retinol-binding protein-4 (RBP4), which is linked to adipose tissue and insulin sensitivity in diabetics. Forty-four women with type 2 diabetes were randomly assigned to three groups for a period of 12 weeks: control (asked to maintain a sedentary lifestyle); resistance exercise (elastic band exercise at moderate intensity five times per week); and aerobic exercise (walking for 60 min at moderate intensity five times per week). Subcutaneous (SCAT), subfascial (SFAT) and intramuscular (IMAT) adipose tissues at mid-thigh level were assessed using computed tomography, and RBP4 level and insulin sensitivity (fractional disappearance rate of insulin, k(ITT)) were assessed before and after intervention. Changes in SCAT, SFAT, IMAT, RBP4 and k(ITT) were similar among the three groups. Within-group analysis revealed that body mass index and waist circumference decreased significantly in both exercise groups, but RBP4 decreased significantly only with resistance exercise. Resistance exercise did not alter muscular adipose tissue or improve insulin sensitivity.
Authors:
Y H Ku; K A Han; H Ahn; H Kwon; B K Koo; H C Kim; K W Min
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of international medical research     Volume:  38     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  782-91     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Eulji University School of Medicine, Daejeon, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Diabetes Mellitus, Type 2 / metabolism*
Female
Humans
Insulin Resistance / physiology
Middle Aged
Muscle, Skeletal / metabolism*
Obesity / physiopathology
Resistance Training*
Retinol-Binding Proteins, Plasma / metabolism*
Chemical
Reg. No./Substance:
0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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