| Resin-composite cytotoxicity varies with shade and irradiance. | |
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MedLine Citation:
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PMID: 22240279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES: The study was aimed at investigating the cytotoxicity of different composites as a function of composite shade and the light curing unit (LCU) employed. METHODS: Non-polymerized and polymerized samples of the composites Grandio(®) (VOCO, Cuxhaven), Solitaire(®) (Heraeus Kulzer, Hanau) and Filtek Z 250(®) (3M/Espe, Seefeld) in two markedly differing shades (A2, C2) were prepared. Polymerization was performed with two LCUs: Heliolux II (Ivoclar/Vivadent, Ellwangen) and Swiss Master Light (EMS, Nyon, Switzerland). To obtain composite extracts, the samples were immersed in cell culture medium (DMEM - Dulbecco's Modified Eagle Medium), which was replaced daily up to the 7th day of the experiment, and then on the 14th, 21st and 28th day. After incubation of human gingival fibroblasts (HGF) with the extracts obtained, cytotoxicity was determined using the MTT test. RESULTS: With the non-polymerized samples, essentially no influence of the composite shades investigated on HGF viability was detected, with the exception of the Solitaire material, where a higher cytotoxicity of the shade C2 in the non-polymerized state was found at the end of the observation period. After polymerization of the different composites, the cytotoxic reaction observed for the extracts of shade C2 was stronger than that observed for A2. After polymerization with the Heliolux II (HLX) LCU, the extracts of composites Grandio and Solitaire C2 were significantly more toxic than those of the A2 shade (p<0.01). Polymerization with the Swiss Master Light (SML) reduces this cytotoxic effect. The extracts of the Grandio composite showed the least cytotoxic effect throughout the observation period, irrespective of the LCU used. For the extracts of the Z250 specimens, the cytotoxicity observed was generally higher. SIGNIFICANCE: The results show that the shade of the composite has an influence on its cytotoxicity and that this cytotoxicity is also influenced by the light curing unit used. It was observed that composites of the darker shade (C2) had a higher cytotoxicity, which varied with the LCU employed. |
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Authors:
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Bernd W Sigusch; Torsten Pflaum; Andrea Völpel; Kerstin Gretsch; Sandra Hoy; David C Watts; Klaus D Jandt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Dental materials : official publication of the Academy of Dental Materials Volume: - ISSN: 1879-0097 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508040 Medline TA: Dent Mater Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Conservative Dentistry, Jena University Hospital, Friedrich-Schiller-Universität Jena, An der alten Post 4, Jena D-07743, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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