Document Detail

Residues of veterinary drugs at injection sites.
MedLine Citation:
PMID:  17217395     Owner:  NLM     Status:  MEDLINE    
Residues of veterinary drugs have potential implications for human food safety and international trade in animal-derived food commodities. A particular concern is the slow depletion of residues of some injectable formulations from the site of administration. Licensing authorities have adopted different approaches to the human food safety assessment of injection site residues. European agencies apply the maximum residue limit (MRL) for muscle to muscle at the injection site and specify a withdrawal period sufficient to ensure the ingestion of a 300 g portion of muscle, if comprised entirely of injection site tissue, does not exceed the acceptable daily intake. The agencies in Australia, Canada and the USA also exclude injection site residues from the MRL-setting process. These agencies evaluate the risk to consumers posed by potential acute manifestations resulting from the infrequent ingestion of injection site residues based on acute dietary exposure considerations. While all of these approaches protect the safety of consumers, the adoption of different approaches has potential implications for residue surveillance programs in the international trade in meat. In particular, when an exporting country establishes standards for residues at injection sites based on acute dietary exposure considerations and the importing country assesses these residues against the MRL for muscle, the unnecessary condemnation of meat and disruption to market access may result. The latter may represent a potential economical impost to the exporting country. An internationally harmonized approach to the risk analysis of residues of veterinary drugs at injection sites, which protects the safety of consumers and facilitates the international trade in meat, is needed.
P T Reeves
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  30     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-12     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-17     Citation Subset:  IM    
Australian Pesticides and Veterinary Medicines Authority, Canberra, Australian Capital Territory, Australia.
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MeSH Terms
Consumer Product Safety / standards*
Drug Residues*
Food Contamination*
Injections / veterinary
Meat / standards*
United States
Veterinary Drugs / adverse effects*
Reg. No./Substance:
0/Veterinary Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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